Ng Chau Yee, Wang Tai-Ang, Lee Hsiang-Chieh, Huang Bo-Huei, Tsai Meng-Tsan
Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333, Taiwan.
Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan 333, Taiwan.
Diagnostics (Basel). 2022 Mar 27;12(4):822. doi: 10.3390/diagnostics12040822.
Fractional laser treatment is commonly used for dermatological applications, enabling effective induction of collagen regeneration and significantly reducing recovery time. However, it is challenging to observe laser-induced photodamage beneath the tissue surface in vivo, making the non-invasive evaluation of treatment outcomes difficult. For in vivo real-time study of the photodamage induced by fractional pulsed CO and Nd:YAG lasers commonly utilized for clinical therapy, a portable spectral-domain optical coherence tomography (SD-OCT) system was implemented for clinical studies. The photodamage caused by two lasers, including photothermal and photoacoustic effects, was investigated using OCT, together with the correlation between photodamage and exposure energy. Additionally, to investigate the change in the optical properties of tissue due to photodamage, the attenuation coefficients and damaged areas of normal skin and laser-treated skin were estimated for comparison. Finally, the recovery of the exposed skin with both lasers was also compared using OCT. The results show that OCT can be a potential solution for in vivo investigation of laser-induced tissue damage and quantitative evaluation.
分数激光治疗常用于皮肤科应用，能够有效诱导胶原蛋白再生并显著缩短恢复时间。然而，在体内观察组织表面下激光诱导的光损伤具有挑战性，使得对治疗结果进行非侵入性评估变得困难。为了对临床治疗中常用的分数脉冲CO和Nd:YAG激光诱导的光损伤进行体内实时研究，采用了一种便携式光谱域光学相干断层扫描（SD-OCT）系统进行临床研究。利用OCT研究了两种激光引起的光损伤，包括光热效应和光声效应，以及光损伤与曝光能量之间的相关性。此外，为了研究光损伤导致的组织光学特性变化，估计并比较了正常皮肤和激光治疗皮肤的衰减系数和损伤面积。最后，还使用OCT比较了两种激光照射后皮肤的恢复情况。结果表明，OCT可能是体内研究激光诱导组织损伤和定量评估的一种潜在解决方案。
