表面活性剂对用于同时递送两种亲水性活性成分的玉米醇溶蛋白流延膜的影响。
Effects of Surfactants on Zein Cast Films for Simultaneous Delivery of Two Hydrophilic Active Components.
作者信息
Wei Dongwei, Zhou Fanhui, Wang Hongdi, Liu Guijin, Fang Jun, Jiang Yanbin
机构信息
School of Chemical Engineering and Materials Science, Quanzhou Normal University, Quanzhou 362000, China.
Key Laboratory of Organosilicon Chemistry and Material Technology, College of Material, Chemistry and Chemical Engineering, Ministry of Education, Hangzhou Normal University, Hangzhou 311121, China.
出版信息
Materials (Basel). 2022 Apr 11;15(8):2795. doi: 10.3390/ma15082795.
In order to prepare edible films with outstanding antimicrobials and antioxidants utilized in applications of food and pharmaceutics, in this study, effects of surfactants on zein cast films for simultaneous delivery of lysozyme (LY) and ascorbic acid (AA) were investigated, where sodium alginate (SA), soy lecithin (SL), and Pluronic f-68 (PF-68) were selected as surfactants. FT-IR tests indicated that SL or PF-68 dramatically changed secondary structure of zein composite films, which heightened the irregularity of the composite film and inhibited LY crystallization. Mechanical tests showed that highly flexible films exhibiting elongations between 129% and 157% were obtained when adding PF-68. Compared with the film without emulsifier, zein film containing SL and PF-68 showed approximately 7.51 and 0.55 times lower initial release rates for LY and AA respectively, which significantly improved the controlled release and heightened the anti-microbial and anti-oxidant activities of the film. Finally, emulsified mechanisms of the surfactants in zein films were proposed.
为了制备在食品和制药应用中具有出色抗菌和抗氧化性能的可食用薄膜，本研究考察了表面活性剂对用于同时递送溶菌酶（LY）和抗坏血酸（AA）的玉米醇溶蛋白流延膜的影响，其中选择海藻酸钠（SA）、大豆卵磷脂（SL）和普朗尼克F-68（PF-68）作为表面活性剂。傅里叶变换红外光谱（FT-IR）测试表明，SL或PF-68显著改变了玉米醇溶蛋白复合膜的二级结构，增加了复合膜的不规则性并抑制了LY结晶。力学测试表明，添加PF-68时可获得具有高柔韧性的薄膜，其伸长率在129%至157%之间。与不含乳化剂的薄膜相比，含有SL和PF-68的玉米醇溶蛋白膜的LY和AA初始释放率分别降低了约7.51倍和0.55倍，这显著改善了控释效果并提高了薄膜的抗菌和抗氧化活性。最后，提出了表面活性剂在玉米醇溶蛋白膜中的乳化机理。
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