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膳食脂肪与冠心病:还有很多有待了解。

Dietary fat and coronary heart disease: there is much more to learn.

作者信息

Oliver M F

出版信息

Cardiology. 1987;74(1):22-7. doi: 10.1159/000174170.

DOI:10.1159/000174170
PMID:3545473
Abstract

The evidence for recommending a reduction of one third or more of dietary fat as a very likely means of reducing coronary heart disease in affluent nations is far from complete. That it will do no harm is an unacceptable scientific argument, and it is still up to the proponents of this policy to prove its long-term safety. I am persuaded, because the facts are very much stronger, that such a diet should be recommended for those who have atherogenic lipoproteins in the top quintile of their distribution. But even in such people, too much should not be expected or promised. What we really need to know is how dietary saturated fat leads to the development of coronary heart disease as well as coronary atherosclerosis; why it may do so in some and not in others; and much more about the effects of specific dietary fatty acids on the mechanisms involved.

摘要

在富裕国家,将膳食脂肪减少三分之一或更多作为降低冠心病可能性的手段,其证据远未完备。声称这样做无害是不可接受的科学论断,仍需该政策的支持者证明其长期安全性。我之所以被说服,是因为事实有力得多,对于那些致动脉粥样硬化脂蛋白分布处于最高五分位数的人群,应该推荐这样的饮食。但即便对于这类人群,也不应抱有过多期望或承诺。我们真正需要了解的是,膳食饱和脂肪如何导致冠心病以及冠状动脉粥样硬化的发展;为何它在某些人身上会导致这种情况,而在另一些人身上却不会;以及更多关于特定膳食脂肪酸对相关机制影响的信息。

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Dietary fat and coronary heart disease: there is much more to learn.膳食脂肪与冠心病:还有很多有待了解。
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