Stanciu Adina Elena, Verzia Andreea, Stanciu Marcel Marian, Zamfirescu Anca, Gheorghe Dan Cristian
Department of Carcinogenesis and Molecular Biology, Institute of Oncology Bucharest, 022328 Bucharest, Romania.
Cernavoda Nuclear Power Plant Division, Nuclearelectrica, 905200 Cernavoda, Romania.
Cancers (Basel). 2022 Apr 9;14(8):1899. doi: 10.3390/cancers14081899.
Publications investigating the effect of radioactive iodine (131I) therapy on the circulating peripheral blood cells in patients with differentiated thyroid cancer (DTC) are limited to blood samples collected more than 92 h after 131I. Studies conducted on blood samples collected up to 92 h are rare due to the radioactive contamination risk. This research aimed to assess the relationship between the prescribed 131I activity, human whole blood activity, and peripheral blood cells at many time points (6, 22, 46, 69, and 92 h after 131I). The study enrolled 50 female patients with DTC who received a 131I median activity of 90.54 mCi (3.35 GBq). The neutrophil-to-lymphocyte ratio (NLR) was measured as an inflammatory marker. 131I uptake in the residual thyroid tissue peaked after 46 h. Blood activity decreased in the first 46 h and increased 69 h after the 131I intake. Blood activity was associated with the absolute lymphocyte count and the NLR at 69 h (r = −0.49 and r = 0.52, p < 0.001). Our results demonstrate that the time interval between 46 and 69 h should be associated with the release of hematological inflammatory mediators, such as neutrophils and lymphocytes, to eradicate tumor cells in response to 131I therapy.
关于放射性碘（¹³¹I）治疗对分化型甲状腺癌（DTC）患者循环外周血细胞影响的研究，仅限于在¹³¹I治疗后92小时以上采集的血样。由于存在放射性污染风险，对在92小时内采集的血样进行的研究很少。本研究旨在评估在多个时间点（¹³¹I治疗后6、22、46、69和92小时）规定的¹³¹I活度、人体全血活度与外周血细胞之间的关系。该研究纳入了50名接受¹³¹I治疗的DTC女性患者，¹³¹I的中位活度为90.54 mCi（3.35 GBq）。测量中性粒细胞与淋巴细胞比值（NLR）作为炎症标志物。残留甲状腺组织中的¹³¹I摄取在46小时后达到峰值。血活度在最初46小时内下降，在¹³¹I摄入后69小时升高。血活度在69小时时与绝对淋巴细胞计数和NLR相关（r = -0.49和r = 0.52，p < 0.001）。我们的结果表明，46至69小时的时间间隔应与血液炎症介质（如中性粒细胞和淋巴细胞）的释放有关，以响应¹³¹I治疗来根除肿瘤细胞。
