Stanciu Adina Elena, Stanciu Marcel Marian, Zamfirescu Anca, Gheorghe Dan Cristian
Department of Carcinogenesis and Molecular Biology, Institute of Oncology Bucharest, 022328 Bucharest, Romania.
Electrical Engineering Faculty, University Politehnica of Bucharest, 060042 Bucharest, Romania.
Cancers (Basel). 2022 May 10;14(10):2359. doi: 10.3390/cancers14102359.
Radioiodine (131I) therapy for differentiated thyroid cancer (DTC) involves exposure of the whole body, including the heart, to ionizing radiation. This exposure to the subsequent risk of heart disease is uncertain, especially in patients with DTC associated with type 2 diabetes mellitus (DTC/+T2DM). The current study aimed to assess the relationship between left ventricular ejection fraction (LVEF), high cumulative 131I dose, and peripheral blood parameters in patients with DTC/−T2DM and DTC/+T2DM. The study enrolled 72 female patients with DTC/−T2DM and 24 with DTC/+T2DM who received cumulative 131I doses above 150 mCi (5.55 GBq). LVEF was lower in patients with concomitant T2DM than those without (p < 0.001). The cumulative 131I dosage was inversely correlated with LVEF only in DTC/−T2DM patients (r = −0.57, p < 0.001). In the DTC/+T2DM group, LVEF was negatively associated with absolute platelet count (r = −0.67, p < 0.001) and platelet-to-lymphocyte ratio (r = −0.76, p < 0.001). Our results demonstrate that exposure to high cumulative 131I doses has different cardiovascular effects in DTC/−T2DM and DTC/+T2DM.
放射性碘（¹³¹I）治疗分化型甲状腺癌（DTC）会使包括心脏在内的全身暴露于电离辐射中。这种暴露对后续患心脏病风险的影响尚不确定，尤其是在患有2型糖尿病（DTC/+T2DM）的DTC患者中。本研究旨在评估DTC/−T2DM和DTC/+T2DM患者的左心室射血分数（LVEF）、高累积¹³¹I剂量与外周血参数之间的关系。该研究纳入了72例接受累积¹³¹I剂量超过150 mCi（5.55 GBq）的DTC/−T2DM女性患者和24例DTC/+T2DM女性患者。伴有T2DM的患者LVEF低于无T2DM的患者（p<0.001）。仅在DTC/−T2DM患者中，累积¹³¹I剂量与LVEF呈负相关（r = -0.57，p<0.001）。在DTC/+T2DM组中，LVEF与血小板绝对计数（r = -0.
