Del Casale Antonio, Paolini Marco, Gentile Giovanna, Borro Marina, Zocchi Clarissa, Fiaschè Federica, Padovano Alessio, Zoppi Teodolinda, Modesti Martina Nicole, De Luca Ottavia, Pomes Leda Marina, Brugnoli Roberto, Ferracuti Stefano, Girardi Paolo, Pompili Maurizio, Simmaco Maurizio
Department of Dynamic and Clinical Psychology, and Health Studies, Faculty of Medicine and Psychology, Sapienza University, Via degli Apuli 2, 00185 Rome, Italy.
Unit of Psychiatry, 'Sant'Andrea' University Hospital, Via di Grottarossa, 00189 Rome, Italy.
J Pers Med. 2022 Apr 2;12(4):565. doi: 10.3390/jpm12040565.
Patients affected by mental disorders smoke more than the general population. The reasons behind this habit are genetic, environmental, etc. This study aims to investigate the correlations between some polymorphisms and the smoking habits and nicotine dependence in patients with psychiatric disorders. We recruited 88 patients with treatment-resistant mental disorders, including 35 with major depressive disorder, 43 with bipolar spectrum disorder, and 10 with schizophrenia spectrum disorder. We carried out a clinical and psychometric assessment on current smoking habits, years of smoking, number of daily cigarettes, and level of nicotine addiction. The patients performed a peripheral blood sample for DNA analyses of different polymorphisms. We searched for correlations between the measures of nicotine addiction and analysed genotypes. The expression of the T allele of the and polymorphisms significantly correlated with a lower level of nicotine dependence and lower use of cigarettes. We did not find significant correlations between nicotine dependence and and polymorphisms, and , or genotype. Concluding, and polymorphisms are involved in nicotine dependence and cigarette smoking habits in patients with treatment-resistant mental disorders.
患有精神障碍的患者比普通人群吸烟更多。这种习惯背后的原因包括遗传、环境等。本研究旨在调查某些多态性与精神疾病患者吸烟习惯和尼古丁依赖之间的相关性。我们招募了88名难治性精神障碍患者，其中包括35名重度抑郁症患者、43名双相谱系障碍患者和10名精神分裂症谱系障碍患者。我们对当前吸烟习惯、吸烟年限、每日吸烟量和尼古丁成瘾水平进行了临床和心理测量评估。患者采集外周血样本用于不同多态性的DNA分析。我们寻找尼古丁成瘾指标与分析的基因型之间的相关性。和多态性的T等位基因表达与较低的尼古丁依赖水平和较少的香烟使用显著相关。我们未发现尼古丁依赖与和多态性、和、或基因型之间存在显著相关性。结论是，和多态性与难治性精神障碍患者的尼古丁依赖和吸烟习惯有关。
