Mitu Ivona, Preda Cristina, Dimitriu Cristina Daniela, Mitu Ovidiu, Costache Irina Iuliana, Ciocoiu Manuela
Department of Morpho-Functional Sciences II, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.
Department of Endocrinology, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.
Healthcare (Basel). 2022 Mar 25;10(4):617. doi: 10.3390/healthcare10040617.
The present study aimed to investigate the association of obesity phenotypes and quality of life (QoL) scales and their relationship with fat mass (FM) parameters.
This study categorized 104 subjects into 4 obesity phenotypes based on BMI and metabolic syndrome status: metabolically healthy obese (MHO), metabolically unhealthy obese (MUO), metabolically healthy non-obese (MHNO), and metabolically unhealthy non-obese (MUNO). Body composition was measured by dual-energy X-ray absorptiometry (DEXA) and metabolic profile was characterized by blood samples. All subjects completed the SF-36 item Short Form Health Survey Questionnaire.
Comparing the four obesity phenotypes, significant results were reported for Bodily Pain between MHNO/MUNO ( = 0.034), for Vitality between MHO/MUO ( = 0.024), and for Mental Component Score between MHO/MUO ( = 0.026) and MUO/MUNO ( = 0.003). A more thorough inside-groups analysis yielded a positive and moderate to high correlation between FM parameters and QoL scales in MHO and MHNO, while a negative and weak to moderate correlation was observed in MUO and MUNO.
This study reported an inverse U-shaped relationship between FM and QoL in obesity phenotypes, suggesting that metabolic status is a key factor involved in modulating QoL and therefore challenging the idea of obesity as a main driver of low QoL. We recommend the inclusion of FM percentage in the definition of obesity phenotypes in future research, to better evaluate QoL of obesity phenotypes.
本研究旨在调查肥胖表型与生活质量（QoL）量表之间的关联及其与脂肪量（FM）参数的关系。
本研究根据体重指数（BMI）和代谢综合征状态将104名受试者分为4种肥胖表型：代谢健康肥胖（MHO）、代谢不健康肥胖（MUO）、代谢健康非肥胖（MHNO）和代谢不健康非肥胖（MUNO）。通过双能X线吸收法（DEXA）测量身体成分，并通过血液样本表征代谢概况。所有受试者均完成了SF-36项简短健康调查问卷。
比较这四种肥胖表型，MHNO/MUNO组之间在身体疼痛方面有显著差异（P = 0.034），MHO/MUO组之间在活力方面有显著差异（P = 0.024），MHO/MUO组之间以及MUO/MUNO组之间在心理成分得分方面有显著差异（P = 0.026和P = 0.003）。更深入的组内分析显示，MHO和MHNO组中FM参数与QoL量表之间存在正相关且为中度到高度相关，而MUO和MUNO组中则观察到负相关且为弱到中度相关。
本研究报告了肥胖表型中FM与QoL之间呈倒U形关系，表明代谢状态是调节QoL的关键因素，因此对肥胖是低QoL的主要驱动因素这一观点提出了挑战。我们建议在未来研究中肥胖表型的定义中纳入FM百分比，以更好地评估肥胖表型的QoL。
