Kwan Byung-Soo, Kim Seung-Chan, Jo Hyen-Chul, Baek Jong-Chul, Park Ji-Eun
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Samsung Changwon Hospital, School of Medicine, Sungkyunkwan University, Changwon-si 51353, Korea.
Biostatistics Cooperation Center, Gyeongsang National University Hospital, Jinju-si 52727, Korea.
Healthcare (Basel). 2022 Mar 30;10(4):649. doi: 10.3390/healthcare10040649.
Studies have assessed the effects of menstrual irregularities and menopause on diabetes, but no definitive conclusion has been reached. This study investigated for the first time the relationship between menstrual irregularity and diabetes before and after menopause.
This population-based cross-sectional study included 9043 participants from the Korea National Health and Nutrition Examination Survey (KNHANES) V (2010-2012). Multivariate logistic regression was used to assess the effect of menstrual irregularities on impaired fasting glucose (IFG) and diabetes incidence in women before and after menopause.
After adjustment for age and other diabetes-related factors, both menopause (OR = 1.51, 95% CI = 1.101-2.27, = 0.047) and menstrual irregularities (OR = 1.51, 95% CI = 1.1-2.07, = 0.011) were found to increase the risk of diabetes. Menstrual irregularities were significantly related to diabetes in the postmenopausal group (OR = 1.65, 95% CI = 1.12-2.42, = 0.012) but not in the premenopausal group (OR = 1.22, 95% CI = 0.64-2.32, = 0.555).
In this study, menopausal status appeared to independently affect diabetes risk; menstrual irregularities were found to be a risk factor for postmenopausal diabetes. This study emphasizes the need for monitoring and early prevention, along with medical advice on menstrual irregularities, to reduce the prevalence of diabetes and improve the quality of life of postmenopausal women.
已有研究评估月经不调和绝经对糖尿病的影响，但尚未得出明确结论。本研究首次调查了绝经前后月经不调与糖尿病之间的关系。
这项基于人群的横断面研究纳入了韩国国家健康与营养检查调查（KNHANES）V（2010 - 2012年）的9043名参与者。采用多因素逻辑回归评估月经不调对绝经前后女性空腹血糖受损（IFG）和糖尿病发病率的影响。
在调整年龄和其他糖尿病相关因素后，发现绝经（OR = 1.51，95%CI = 1.101 - 2.27，P = 0.047）和月经不调（OR = 1.51，95%CI = 1.1 - 2.07，P = 0.011）均会增加患糖尿病的风险。月经不调在绝经后组与糖尿病显著相关（OR = 1.65，95%CI = 1.12 - 2.42，P = 0.012），而在绝经前组则无显著相关性（OR = 1.22，95%CI = 0.64 - 2.32，P = 0.555）。
在本研究中，绝经状态似乎独立影响糖尿病风险；月经不调被发现是绝经后糖尿病的一个危险因素。本研究强调需要进行监测和早期预防，以及提供有关月经不调的医学建议，以降低糖尿病患病率并改善绝经后女性的生活质量。
