Nardelli E, De Benedictis G, La Stilla G, Nicolardi G
Clin Neuropathol. 1986 Nov-Dec;5(6):261-6.
Clinical, neuropathological, and immunohistochemical (PAP) findings are reported in a 7 month-old girl with Tuberous sclerosis (TS). Polycystic kidneys and massive cardiomegaly constituted the prominent pathological features. The neuropathology of the syndrome was characterized by Megalencephaly, Subependymal giant cell astrocytoma, Very large protoplasmic astrocytes in Golgi-rapid method preparations of cortical tubers and Glial fibrillary acidic protein (GFAP)-negative giant cells in the subependymal nodules as well as in the cortical tubers. The identity of these giant cells is discussed.
报告了一名患有结节性硬化症（TS）的7个月大女孩的临床、神经病理学和免疫组织化学（PAP）检查结果。多囊肾和重度心脏肥大是主要的病理特征。该综合征的神经病理学特征为巨脑症、室管膜下巨细胞星形细胞瘤、在皮质结节的高尔基快速法制备物中可见非常大的原浆性星形细胞，以及在室管膜下结节和皮质结节中存在胶质纤维酸性蛋白（GFAP）阴性的巨细胞。文中讨论了这些巨细胞的特性。
