Division of Infections and Molecular Biology, Faculty of Dentistry, Kyushu Dental University, Fukuoka 803-8580, Japan.
School of Oral Health Sciences, Faculty of Dentistry, Kyushu Dental University, Fukuoka 803-8580, Japan.
Int J Environ Res Public Health. 2022 Apr 14;19(8):4734. doi: 10.3390/ijerph19084734.
Background: Periodontal pathogens are related to the incidence of systemic diseases. This study aimed to examine whether periodontal pathogen burden is associated with the risk of fever onset in older adults. Methods: Older adults in nursing homes, aged ≥65 years, were enrolled. The study was set in Kitakyushu, Japan. The body temperatures of participants were ≥37.2 °C and were recorded for eight months. As periodontal pathogens, Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia were qualified by a real-time polymerase chain reaction at the baseline. For statistical analysis, the number of bacterial counts was logarithmically conversed to 10 as a base. Results: Data from 56 participants with a median age of 88 (62−98) years were available for analysis. The logarithmic-conversed bacterial counts of T. forsythia, but not P. gingivalis or T. denticola, were associated with the onset of fever in older residents. The Kaplan−Meier method revealed that the group with <104 of T. forsythia had significantly less cumulative fever incidence than the group with ≥104 of T. forsythia. The group with ≥104 of T. forsythia was associated with an increased risk of fever onset (hazard ratio, 3.7; 98% confidence interval, 1.3−10.2; p = 0.012), which was adjusted for possible confounders. Conclusions: Bacterial burden of T. forsythia in the oral cavity was associated with the risk of the onset of fever in older nursing homes residents.
牙周病原体与全身疾病的发生有关。本研究旨在探讨牙周病原体负担是否与老年人发热的风险相关。
纳入养老院≥65 岁的老年人。研究在日本北九州市进行。参与者的体温≥37.2°C 并记录了八个月。在基线时，通过实时聚合酶链反应确定了牙龈卟啉单胞菌、牙髓密螺旋体和福赛坦纳氏菌为牙周病原体。为了统计分析，细菌计数的数量被对数转换为以 10 为底的对数。
56 名参与者（中位年龄 88 岁[62-98 岁]）的数据可用于分析。福赛坦纳氏菌的对数转换细菌计数与老年居民发热的发生有关，但牙龈卟啉单胞菌或牙髓密螺旋体无关。Kaplan-Meier 法显示，T. forsythia<104 的组与 T. forsythia≥104 的组相比，累积发热发生率显著较低。T. forsythia≥104 的组与发热发生的风险增加相关（危险比，3.7；98%置信区间，1.3-10.2；p=0.012），这是在调整了可能的混杂因素之后得出的。
口腔中福赛坦纳氏菌的细菌负担与养老院老年人发热的风险相关。
