Department of Hematology, Nagasaki University Hospital, Nagasaki 852-8501, Japan.
Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8501, Japan.
Viruses. 2022 Apr 11;14(4):791. doi: 10.3390/v14040791.
Nationwide surveys of adult T-cell leukemia/lymphoma (ATL) have played an important role in helping us to understand the pathophysiology of this disease and analyze its prognosis in Japan. Classifications of clinical subtypes have been proposed based on the results of nationwide surveys of patients with ATL diagnosed in the 1980s. This article highlighted the classification and prognosis of ATL based on different surveys and focused on the comparison of data derived from the available surveys. The 11th nationwide hospital-based survey was conducted in patients with ATL diagnosed in 2010-2011 using the same method as that used in the 1980s survey. The median age of disease onset was 68 years, which was increased compared with previous surveys. While median survival of patients with the acute and lymphoma types had not improved much since the 1980s, the 4-year survival rate was higher. Little improvement in the prognosis was observed for the chronic and smoldering types. The 12th nationwide survey of patients with ATL diagnosed in 2012-2013 also showed an increase in age at onset. Further epidemiological research that includes more cases is needed to deepen our understanding of the actual state of treatment and prognosis of this disease.
全国性的成人 T 细胞白血病/淋巴瘤（ATL）调查在帮助我们了解这种疾病的病理生理学和分析其在日本的预后方面发挥了重要作用。根据 20 世纪 80 年代诊断的 ATL 患者的全国性调查结果，提出了临床亚型的分类。本文根据不同的调查强调了 ATL 的分类和预后，并重点比较了现有调查数据。2010-2011 年使用与 20 世纪 80 年代调查相同的方法对 ATL 患者进行了第 11 次全国性以医院为基础的调查。发病中位年龄为 68 岁，与以前的调查相比有所增加。虽然自 20 世纪 80 年代以来，急性和淋巴瘤型患者的中位生存时间没有明显改善，但 4 年生存率更高。慢性和亚临床型患者的预后改善不大。2012-2013 年对 ATL 患者的第 12 次全国性调查也显示发病年龄增加。需要进行更多病例的进一步流行病学研究，以加深我们对这种疾病的实际治疗和预后状况的理解。
