Cdc25 磷酸酶抑制剂的发展综述。

Plant Advanced Technologies (PAT), 54500 Vandoeuvre-les-Nancy, France.

National Research Centre, Chemistry of Natural Compounds Department, Dokki, Cairo 12622, Egypt.

Molecules. 2022 Apr 7;27(8):2389. doi: 10.3390/molecules27082389.

Cdc25 phosphatases have been considered promising targets for anticancer development due to the correlation of their overexpression with a wide variety of cancers. In the last two decades, the interest in this subject has considerably increased and many publications have been launched concerning this issue. An overview is constructed based on data analysis of the results of the previous publications covering the years from 1992 to 2021. Thus, the main objective of the current review is to report the chemical structures of Cdc25s inhibitors and answer the question, how to design an inhibitor with better efficacy and lower toxicity?

由于 Cdc25 磷酸酶的过度表达与多种癌症相关，因此它们一直被认为是癌症治疗的有前途的靶点。在过去的二十年中，人们对这个课题的兴趣大大增加，并且已经发表了许多关于这个问题的出版物。本综述基于对 1992 年至 2021 年期间的先前出版物的结果进行数据分析，构建了一个概述。因此，本综述的主要目的是报告 Cdc25 抑制剂的化学结构，并回答如何设计一种疗效更好、毒性更低的抑制剂的问题。