β-甘氨酰胺核苷酸的立体选择性合成。
Stereoselective Synthesis of β-Glycinamide Ribonucleotide.
机构信息
Department of Chemistry, Northeastern University, Boston, MA 02115, USA.
出版信息
Molecules. 2022 Apr 14;27(8):2528. doi: 10.3390/molecules27082528.
Abstract
A diastereoselective synthesis of the β-anomer of glycinamide ribonucleotide (β-GAR) has been developed. The synthesis was accomplished in nine steps from D-ribose and occurred in 5% overall yield. The route provided material on the multi-milligram scale. The synthetic β-GAR formed was remarkably resistant to anomerization both in solution and as a solid.
摘要
已开发出甘氨酰胺核苷酸（β-GAR）β-异构体的非对映选择性合成方法。该合成从 D-核糖出发经 9 步反应完成，总收率为 5%。该路线提供了毫克级别的大量产物。所合成的β-GAR 在溶液中和作为固体时都非常稳定，不易发生差向异构化。
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