Filipová Lenka, Lazúrová Ivica
Vnitr Lek. 2021 Winter;67(E-8):19-22.
Tumor induced osteomalacia (TIO) is a rare paraneoplastic syndrome typically caused by small endocrine tumors that secrete fibroblast growth factor 23(FGF23). TIO is clinically characterized by progressive muskuloskeletal pain, fatigue, proximal muscle weakness, and multiple fractures that lead to long-term disability. Due to the non-specific symptoms of the disease, it may take several years for them to be properly diagnosed and treated, so it is important to better inform about this rare paraneoplastic syndrome.
肿瘤诱导性骨软化症（TIO）是一种罕见的副肿瘤综合征，通常由分泌成纤维细胞生长因子23（FGF23）的小内分泌肿瘤引起。TIO的临床特征为进行性肌肉骨骼疼痛、疲劳、近端肌无力以及导致长期残疾的多发性骨折。由于该疾病症状不具特异性，可能需要数年时间才能得到正确诊断和治疗，因此更好地宣传这种罕见的副肿瘤综合征很重要。
