Sørensen Sarah M, de la Cour Cecilie D, Maltesen Thomas, Urbute Aivara, Kjaer Susanne K
Unit of Virus, Lifestyle and Genes; Copenhagen, Denmark.
Statistics and Data Analysis; Danish Cancer Society Research Center, Copenhagen, Denmark.
Thyroid. 2022 Aug;32(8):972-982. doi: 10.1089/thy.2021.0602. Epub 2022 Jun 27.
Thyroid cancer incidence has increased over the past decades. Differences in incidence trends have been observed depending on socioeconomic status. Here, we describe trends in the incidence of papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC) in Denmark by level of education and income. All PTC and FTC cases registered in the Danish Cancer Registry from 1995 to 2019 were identified. Individual-level information on education and income was obtained from nationwide registries. We calculated age-standardized incidence rates according to sex, tumor size, education and income, and estimated incidence trends by average annual percentage change (AAPC) and corresponding confidence intervals [CIs] for the periods 1995 to 2004 and 2005 to 2019 by using Poisson regression models. We identified 3454 cases of PTC and 972 cases of FTC. From 2005 to 2019 among women, the incidence of PTC increased across all levels of education (AAPC = 12.5% [CI 9.8 to 15.3]; AAPC = 8.1% [CI 6.4 to 9.9]; AAPC = 7.3% [CI 5.4 to 9.2]). The same pattern was seen for income. The incidence of FTC increased in all levels of education (AAPC = 10.5% [CI 5.8 to 15.4]; AAPC = 4.0% [CI 0.9 to 7.3]; AAPC = 4.3% [CI 0.6 to 8.1]), with the same pattern for income. Similar trends were observed among men, in both small (≤2 cm) and large (>2 cm) PTCs and from 1995 to 2004 in both sexes. Enhanced detection of thyroid cancer among all levels of education and income cannot be ruled out, and in addition, our results may suggest a true increase in the incidence of differentiated thyroid cancer.
在过去几十年中，甲状腺癌的发病率有所上升。根据社会经济地位的不同，发病率趋势也有所差异。在此，我们按教育程度和收入水平描述丹麦乳头状甲状腺癌（PTC）和滤泡状甲状腺癌（FTC）的发病率趋势。确定了1995年至2019年在丹麦癌症登记处登记的所有PTC和FTC病例。关于教育和收入的个人层面信息来自全国性登记处。我们根据性别、肿瘤大小、教育程度和收入计算年龄标准化发病率，并使用泊松回归模型估计1995年至2004年以及2005年至2019年期间的发病率趋势，以平均年百分比变化（AAPC）和相应的置信区间[CI]表示。我们确定了3454例PTC病例和972例FTC病例。在2005年至2019年期间，女性中，所有教育程度的PTC发病率均有所上升（AAPC = 12.5% [CI 9.8至15.3]；AAPC = 8.1% [CI 6.4至9.9]；AAPC = 7.3% [CI 5.4至9.2]）。收入方面也呈现相同模式。所有教育程度的FTC发病率均上升（AAPC = 10.5% [CI 5.8至15.4]；AAPC = 4.0% [CI 0.9至7.3]；AAPC = 4.3% [CI 0.6至8.1]），收入方面也是如此。在男性中也观察到类似趋势，在小（≤2 cm）和大（>2 cm）PTC中均是如此，并且在1995年至2004年期间男女皆是如此。不能排除在所有教育程度和收入水平中甲状腺癌检测率提高的可能性，此外，我们的结果可能表明分化型甲状腺癌的发病率确实有所上升。
