Hossain M, Hall S C, Wiggington P J, Roth S M, Das S, Das U, Roayapalley P K, Dimmock J R
School of Sciences, Indiana University Kokomo, Kokomo, USA;, Email:
School of Sciences, Indiana University Kokomo, Kokomo, USA.
Pharmazie. 2022 Apr 10;77(3):90-94. doi: 10.1691/ph.2022.11072.
The present investigation involved the synthesis of a number of novel benzylidene hydrazides as candidate cytotoxic agents. The preparation of these compounds from terephthalic acid and isophthalic acid proceeded satisfactorily. However, the reaction of phthalic acid hydrazide with various aryl aldehydes was unsuccessful in general. Some of the unexpected products were identified. The shapes and also the distances between the centers of the aryl rings designated B and C of three representative compounds , and were determined. The compounds designated , and were screened against human HCT116 and HT29 colon cancer cells as well as human CRL1790 non-malignant colon cells which revealed the tumor-selective toxicity displayed by these compounds.
