Division of Otolaryngology-Head and Neck Surgery, George Washington University School of Medicine and Health Sciences, 2300 M Street, NW, 4th Floor, Washington, DC, 20037, USA.
Division of Hematology and Oncology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Eur Arch Otorhinolaryngol. 2022 Sep;279(9):4533-4540. doi: 10.1007/s00405-022-07387-7. Epub 2022 Apr 23.
Platinum and taxane-based neoadjuvant chemotherapy with surgery (NAC + S) is a novel de-intensified treatment modality that is currently under investigation.
All patients treated for HPV positive OPSCC with NAC + S at a single institution between 2006 and 2020 were contacted to complete the University of Washington Quality of life questionnaire (UW-QOL) at least 2 years following the completion of treatment.
The UW-QOL surveys were received from 25 of 48 eligible patients (52.1%). The mean follow-up time was 4.3 years (range 2.0-7.6 years). The overall mean score for the physical subscale was 92.4 (Standard deviation, SD = 10.9), and the social-emotional subscale was 91.1 (11.8). Compared to the normative cohort, the NAC + S cohort had a worse appearance (Mean scores Normative vs. NAC + S: 93 vs. 84.0, p = 0.009).
NAC + S offers favorable long-term QOL, as evidenced by near-normal scores in most QOL domains.
含铂类和紫杉类药物的新辅助化疗联合手术（NAC+S）是一种新的去强化治疗方式，目前正在研究中。
在 2006 年至 2020 年期间，在一家机构接受 NAC+S 治疗 HPV 阳性口咽鳞状细胞癌的所有患者都被联系，要求在完成治疗后至少 2 年完成华盛顿大学生活质量问卷（UW-QOL）。
共收到 48 名符合条件的患者中的 25 名（52.1%）的 UW-QOL 调查。平均随访时间为 4.3 年（范围 2.0-7.6 年）。身体子量表的总体平均得分为 92.4（标准差，SD=10.9），社会情感子量表为 91.1（11.8）。与规范队列相比，NAC+S 队列的外观更差（规范队列与 NAC+S 队列的平均得分：93 与 84.0，p=0.009）。
NAC+S 提供了有利的长期生活质量，大多数生活质量领域的得分接近正常。
