Lam W K, Chau P Y, So S Y, Leung Y K, Chan J C, Sham M K
Infection. 1986;14 Suppl 4:S290-2. doi: 10.1007/BF01661296.
32 hospitalized adult patients with infective episodes of bronchiectasis were enrolled in an ongoing double-blind, placebo-controlled study comparing ofloxacin with amoxicillin. They were randomized to receive either 200 mg ofloxacin or 1 g amoxicillin, both t.i.d. orally for ten days. In the ofloxacin group (15 patients), clinical response was excellent (clinical cure) in 11 and fair (clinical improvement or early reinfection) in three patients with one failure. In the amoxicillin group (17 patients), clinical response was excellent in six, fair in five, and poor (treatment failure) in six patients. Ofloxacin levels at 2 h (day 5) were 2.3 to 8.2 mg/l (mean 3.9 mg/l) for serum and 1.3 to 15 mg/l (mean 4.5 mg/l) for sputum. Sputum: serum ratio was 1.2:1. Amoxicillin levels at 2 h were 10 to 40 mg/l (mean 19.9 mg/l) for serum and 0 to 1.5 mg/l (mean 0.3 mg/l) for sputum, with no amoxicillin detected in sputum in 10 of 17 patients. Sputum: serum ratio was 0.02:1. One patient in the ofloxacin group had nausea. In the amoxicillin group, four patients had nausea and stomach pain, one had vertigo and one had transient peripheral eosinophilia. Ofloxacin thus yielded higher sputum concentration and appeared to be more effective and better tolerated than amoxicillin in infective episodes of bronchiectasis.
32例患有支气管扩张感染发作的住院成年患者参与了一项正在进行的双盲、安慰剂对照研究，该研究比较了氧氟沙星与阿莫西林。他们被随机分配接受200毫克氧氟沙星或1克阿莫西林，均每日口服三次，共十天。在氧氟沙星组（15例患者）中，11例临床反应极佳（临床治愈），3例反应尚可（临床改善或早期再感染），1例治疗失败。在阿莫西林组（17例患者）中，6例临床反应极佳，5例反应尚可，6例反应不佳（治疗失败）。第5天2小时时，血清中氧氟沙星水平为2.3至8.2毫克/升（平均3.9毫克/升），痰液中为1.3至15毫克/升（平均4.5毫克/升）。痰液与血清的比例为1.2:1。2小时时，血清中阿莫西林水平为10至40毫克/升（平均19.9毫克/升），痰液中为0至1.5毫克/升（平均0.3毫克/升），17例患者中有10例痰液中未检测到阿莫西林。痰液与血清的比例为0.02:1。氧氟沙星组有1例患者出现恶心。在阿莫西林组中，4例患者出现恶心和胃痛，1例出现眩晕，1例出现短暂性外周嗜酸性粒细胞增多。因此，在支气管扩张感染发作中，氧氟沙星产生的痰液浓度更高，似乎比阿莫西林更有效且耐受性更好。
