Carney S L, Morgan T O
Int J Clin Pharmacol Ther Toxicol. 1986 Dec;24(12):665-7.
The effect of a maximal dose of a commonly used diuretic, chlorthalidone, on renal function was assessed in 6 patients with untreated essential hypertension. 100 mg daily of chlorthalidone for a 4-week period produced a significant fall in the plasma potassium concentration and total body potassium content by 16 and 4.2%, respectively. Associated with this change in body potassium status was a 10% decrease in the maximum urine concentrating capacity (p less than 0.01). Renal plasma flow, but not glomerular filtration rate, was also depressed (9.2%) by diuretic therapy. These results suggest that small diuretic induced deficits in the plasma potassium concentration as well as the total body potassium status interfere with renal tubular function.
在6例未经治疗的原发性高血压患者中评估了常用利尿剂氯噻酮最大剂量对肾功能的影响。连续4周每日服用100 mg氯噻酮可使血浆钾浓度和总体钾含量分别显著下降16%和4.2%。伴随机体钾状态的这种变化，最大尿浓缩能力下降了10%（P<0.01）。利尿剂治疗还使肾血浆流量降低（9.2%），但肾小球滤过率未受影响。这些结果表明，利尿剂引起的血浆钾浓度以及总体钾状态的轻微降低会干扰肾小管功能。
