Department of Urology, Toho University Sakura Medical Center, Chiba 285-8741, Japan.
QST Hospital, National Institutes for Quantum Science and Technology, Chiba, Japan, Chiba 263-8555, Japan.
Jpn J Clin Oncol. 2022 Aug 5;52(8):950-953. doi: 10.1093/jjco/hyac066.
The aim of this study was to reclassify high-risk prostate cancer patients treated with carbon-ion radiotherapy and androgen deprivation therapy using the Candiolo nomogram and evaluate usefulness to predict the following 10-year biochemical recurrence. Six hundred seventy-two high-risk prostate cancer patients were reclassified according to the Candiolo nomogram. The cumulative incidence curves for biochemical recurrence were compared by Gray's test. Furthermore, five predictors of the Candiolo nomogram in our patients were evaluated by Fine and Gray regression hazards model. The higher the Candiolo risk, the worse the biochemical recurrence, especially in high- and very high-risk patients. Out of five predictors, age ≥70 years, cT3 stage, biopsy Gleason score ≥9 or the percentage of positive biopsy cores ≥50% had significant impacts on 10-year biochemical recurrence in our patients. The Candiolo nomogram can reclassify our high-risk prostate cancer patients treated with carbon-ion radiotherapy and androgen deprivation therapy and evaluate the biochemical recurrence preciously.
本研究旨在使用坎迪奥洛列线图对接受碳离子放疗和雄激素剥夺治疗的高危前列腺癌患者进行重新分类，并评估其预测以下 10 年生化复发的有用性。根据坎迪奥洛列线图，对 672 例高危前列腺癌患者进行重新分类。通过灰色检验比较生化复发的累积发生率曲线。此外，通过 Fine 和 Gray 回归风险模型评估了我们患者中坎迪奥洛列线图的五个预测因素。坎迪奥洛风险越高，生化复发越差，尤其是在高风险和极高风险患者中。在五个预测因素中，年龄≥70 岁、cT3 期、活检 Gleason 评分≥9 或阳性活检核心百分比≥50%对我们患者的 10 年生化复发有显著影响。坎迪奥洛列线图可以对接受碳离子放疗和雄激素剥夺治疗的高危前列腺癌患者进行重新分类，并准确评估生化复发情况。
