Lala Murad
Department of Surgical Oncology, PD Hinduja National Hospital and Research Centre, Mumbai, India.
Indian J Surg Oncol. 2022 Mar;13(1):143-151. doi: 10.1007/s13193-021-01319-3. Epub 2021 Apr 27.
Primary hyperparathyroidism (PHPT) is the unregulated overproduction of parathyroid hormone (PTH) resulting in abnormal calcium homeostasis. The disease profile has evolved over the last century from symptomatic hyperparathyroidism to asymptomatic hyperparathyroidism. Primary hyperparathyroidism is a biochemical diagnosis. Parathyroidectomy is the only established cure for this disease. Every effort is made to localize the offending gland preoperaively with various imaging modalities. These localization studies along with intraoperative parathormone monitoring will direct the surgeon to either a focused parathyroidectomy or a four gland exploration. All symptomatic patients and asymptomatic patients who meet the criteria for surgery should undergo parathyroidectomy if no medical contraindications exist. Pharmacologic approaches are reserved for those patients unfit or unwilling to undergo surgery.
原发性甲状旁腺功能亢进症（PHPT）是甲状旁腺激素（PTH）不受调控地过度分泌，导致钙稳态异常。在过去一个世纪中，该疾病的特征已从有症状的甲状旁腺功能亢进发展为无症状的甲状旁腺功能亢进。原发性甲状旁腺功能亢进症是一种生化诊断。甲状旁腺切除术是治疗该疾病唯一已确立的方法。术前会尽一切努力通过各种成像方式定位病变腺体。这些定位研究以及术中甲状旁腺激素监测将指导外科医生进行聚焦甲状旁腺切除术或双侧探查术。如果没有医学禁忌证，所有有症状的患者以及符合手术标准的无症状患者均应接受甲状旁腺切除术。药物治疗方法适用于那些不适合或不愿意接受手术的患者。
