Department of Geriatrics, The First People's Hospital of Lianyungang, Lianyungang, China.
Xuzhou Medical University Affiliated the Hospital of Lianyungang, The First Affiliated the Hospital of Kangda College of Nangjing Medical University, Jiangsu 222000, China.
J Healthc Eng. 2022 Apr 14;2022:9003537. doi: 10.1155/2022/9003537. eCollection 2022.
This paper explores the diagnostic value of Hcy combined with the blood pressure variability index in the severity of hypertension complicated with CSVD and its correlation with cognitive function and CysC expression. 200 patients with ischemic small cerebral vessels are selected as the research object. According to the MRI findings, they are divided into 48 cases of white matter lesions (WML), 44 cases of lacunar infarction (LI), 44 cases of enlarged perivascular spaces (EPVs), and 46 cases in the mixed group (referring to two or more types of ischemic cerebrovascular disease on imaging). Different cognitive domains of different types of ischemic cerebrovascular diseases are analyzed. The risk factors of cognitive decline in patients with ischemic cerebrovascular disease are analyzed by univariate analysis and multivariate logistic regression analysis. There is an ancestral correlation between serum Hcy and CSVD, which is an independent risk factor for CSVD.
本文探讨了 Hcy 联合血压变异指数对高血压合并 CSVD 严重程度的诊断价值及其与认知功能和 CysC 表达的相关性。选取 200 例缺血性小血管病患者为研究对象,根据 MRI 结果分为脑白质病变(WML)48 例、腔隙性梗死(LI)44 例、血管周围间隙扩大(EPVs)44 例和混合组(影像学上同时存在两种或两种以上类型的缺血性脑血管病)46 例。分析不同类型缺血性脑血管病患者不同认知领域的情况。采用单因素分析和多因素 logistic 回归分析缺血性脑血管病患者认知下降的危险因素。血清 Hcy 与 CSVD 之间存在家族相关性,是 CSVD 的独立危险因素。