来自[具体来源未明确]的生物活性成分对HCT116结肠癌细胞具有生长抑制作用，并对RAW 264.7巨噬细胞具有抗炎能力。

Bioactive Components From With Growth Inhibition on HCT116 Colon Cancer Cells and Anti-inflammatory Capacity in RAW 264.7 Macrophages.

作者信息

Yi Lingxiao, Wang Qi, Luo Haiyan, Lei Daqing, Tang Zhonghai, Lei Sijia, Xiao Hang

机构信息

Department of Food Science, University of Massachusetts, Amherst, MA, United States.

School of Food and Drug, Shenzhen Polytechnic, Shenzhen, China.

出版信息

Front Nutr. 2022 Apr 6;9:856282. doi: 10.3389/fnut.2022.856282. eCollection 2022.

is rich in bioactive compounds with various potential health benefits. This study aimed to elucidate the profile of both extractable bioactive components (EBCs) and non-extractable bioactive components (NEBCs) of and determine their anti-colon cancer and anti-inflammatory activities. Both EBCs and NEBCs displayed strong suppressive effects on the viability of HCT116 cells, which causes cell cycle arrest, induces cellular apoptosis, and regulates the expression of cyclin-dependent kinases (CDKs) and tumor suppressor proteins. Additionally, EBCs and NEBCs from displayed anti-inflammatory functions inhibiting the production of nitric oxide (NO), reactive oxygen species (ROS), and proinflammatory cytokines in activated macrophages and regulating the expression levels of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), NADPH-quinone oxidoreductase-1 (NQO-1), and heme oxygenase 1 (HO-1). These findings provide a rationale for animal and human studies designed to evaluate the chemopreventive and anti-inflammatory potential of these bioactive compounds from .

富含具有多种潜在健康益处的生物活性化合物。本研究旨在阐明[具体物质]的可提取生物活性成分（EBCs）和不可提取生物活性成分（NEBCs）的概况，并确定它们的抗结肠癌和抗炎活性。EBCs和NEBCs对HCT116细胞的活力均表现出强烈的抑制作用，这会导致细胞周期停滞、诱导细胞凋亡，并调节细胞周期蛋白依赖性激酶（CDKs）和肿瘤抑制蛋白的表达。此外，[具体物质]中的EBCs和NEBCs具有抗炎功能，可抑制活化巨噬细胞中一氧化氮（NO）、活性氧（ROS）和促炎细胞因子的产生，并调节环氧合酶-2（COX-2）、诱导型一氧化氮合酶（iNOS）、NADPH-醌氧化还原酶-1（NQO-1）和血红素加氧酶1（HO-1）的表达水平。这些发现为旨在评估这些来自[具体物质]的生物活性化合物的化学预防和抗炎潜力的动物和人体研究提供了理论依据。