División Académica de Ciencias Básicas. CICTAT. Laboratorio de Bioquímica y Biología Molecular., Universidad Juárez Autónoma de Tabasco, Cunduacán,, Tabasco., 86690, Mexico.
Laboratorio de Análisis Clínicos., Secretaría de Salud, Hospital General de Comalcalco., Comalcalco., Tabasco, 86300, Mexico.
F1000Res. 2022 Jan 6;11:10. doi: 10.12688/f1000research.74023.2. eCollection 2022.
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is the etiological agent of the coronavirus disease 2019 (COVID-19) pandemic. Among the risk factors associated with the severity of this disease is the presence of several metabolic disorders. For this reason, the aim of this research was to identify the comorbidities and laboratory parameters among COVID-19 patients admitted to the intensive care unit (ICU), comparing the patients who required invasive mechanical ventilation (IMV) with those who did not require IMV, in order to determine the clinical characteristics associated with the COVID-19 severity. We carried out a cross-sectional study among 152 patients who were admitted to the ICU from April 1 to July 31 , 2021, in whom the comorbidities and laboratory parameters associated with the SARS-CoV-2 infection severity were identified. The data of these patients was grouped into two main groups: "patients who required IMV" and "patients who did not require IMV". The nonparametric Mann-Whitney U test for continuous data and the test for categorical data were used to compare the variables between both groups. Of the 152 COVID-19 patients who were admitted to the ICU, 66 required IMV and 86 did not require IMV. Regarding the comorbidities found in these patients, a higher prevalence of type 2 diabetes mellitus (T2DM), hypertension and obesity was observed among patients who required IMV vs. those who did not require IMV ( ). Concerning laboratory parameters, only glucose, Interleukin 6 (IL-6), lactate dehydrogenase (LDH) and C-reactive protein (CRP) were significantly higher among patients who required IMV than in those who did not require IMV ( ). This study performed in a Mexican population indicates that comorbidities such as: T2DM, hypertension and obesity, as well as elevated levels of glucose, IL-6, LDH and CRP are associated with the COVID-19 severity.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）是 2019 年冠状病毒病（COVID-19）大流行的病原体。与这种疾病严重程度相关的危险因素之一是存在几种代谢紊乱。因此，本研究的目的是确定入住重症监护病房（ICU）的 COVID-19 患者的合并症和实验室参数，比较需要有创机械通气（IMV）的患者与不需要 IMV 的患者，以确定与 COVID-19 严重程度相关的临床特征。
我们对 2021 年 4 月 1 日至 7 月 31 日期间入住 ICU 的 152 名患者进行了横断面研究，确定了与 SARS-CoV-2 感染严重程度相关的合并症和实验室参数。将这些患者的数据分为两组：“需要 IMV 的患者”和“不需要 IMV 的患者”。使用连续数据的非参数 Mann-Whitney U 检验和分类数据的 检验比较两组之间的变量。
在入住 ICU 的 152 名 COVID-19 患者中，有 66 名需要 IMV，86 名不需要 IMV。对于这些患者发现的合并症，需要 IMV 的患者比不需要 IMV 的患者中 2 型糖尿病（T2DM）、高血压和肥胖的患病率更高（ ）。关于实验室参数，只有葡萄糖、白细胞介素 6（IL-6）、乳酸脱氢酶（LDH）和 C 反应蛋白（CRP）在需要 IMV 的患者中明显高于不需要 IMV 的患者（ ）。
这项在墨西哥人群中进行的研究表明，合并症如：T2DM、高血压和肥胖，以及葡萄糖、IL-6、LDH 和 CRP 水平升高与 COVID-19 的严重程度相关。
