Gualdi Giulio, Bruni Manfredo, Giuliani Federica, Gisondi Paolo, Amerio Paolo
Drs. Gualdi, Giuliani and Amerio are with the Dermatologic Clinic, Department of Medicine and Aging Science, at University D'Annunzio Chieti-Pescara in Chieti, Italy.
Dr. Bruni and Prof. Gisondi are with the Department of Medicine, Section of Dermatology and Venereology, at the University of Verona in Verona, Italy.
J Clin Aesthet Dermatol. 2022 Apr;15(4):36-38.
Epidermal barrier defects have been described in psoriatic lesions. Transepidermal water loss (TEWL) is the measure of steady-state water vapor flux crossing the skin to the external environment, and it has been used extensively to characterize skin barrier function. We evaluated how biological treatments impact TEWL in with psocratic patients.
TEWL measurements were collected from psoriatic lesions and from adjacent unaffected skin areas before introducing a biological anti-tumor necrosis factor (TNF) alpha treatment and after six months of therapy.
Our data show that the skin barrier function is restored after biologic therapy. Analysis of healthy skin values, indicated significant increases in TEWL.
A restoration of TEWL on psoriatic lesions was coupled with an alteration of this parameter in nonlesional skin of all patients, underscoring the general homeostatic effect of an anti-TNF on the integrity of skin barrier. These results suggest the need of an emollient therapy in patients with psoriasis undergoing systemic biological treatment.
银屑病皮损中存在表皮屏障缺陷。经表皮水分流失（TEWL）是衡量稳态水蒸气通量穿过皮肤进入外部环境的指标，已被广泛用于表征皮肤屏障功能。我们评估了生物治疗对银屑病患者TEWL的影响。
在引入生物抗肿瘤坏死因子（TNF）α治疗前以及治疗六个月后，从银屑病皮损和相邻未受影响的皮肤区域收集TEWL测量值。
我们的数据表明，生物治疗后皮肤屏障功能得以恢复。对健康皮肤值的分析表明TEWL显著增加。
银屑病皮损处TEWL的恢复与所有患者非皮损皮肤中该参数的改变相关，强调了抗TNF对皮肤屏障完整性的总体稳态作用。这些结果表明，接受全身生物治疗的银屑病患者需要进行润肤治疗。
