Stern P L, Beresford N, Bell S M, Thompson S, Jones K, Mellor A
J Immunogenet. 1986 Apr-Jun;13(2-3):133-40. doi: 10.1111/j.1744-313x.1986.tb01094.x.
Previous work has concluded that murine embryonal carcinoma (EC) cells, the oncogenic stem cells of teratocarcinomas, do not express class-I, H-2K or D/L gene encoded products. Experiments using cell-mediated lysis, serological and molecular biological approaches show that EC cells do express some major histocompatibility complex (MHC) class I or class I-like molecules.
先前的研究得出结论,小鼠胚胎癌(EC)细胞,即畸胎癌的致癌干细胞,不表达I类、H-2K或D/L基因编码产物。使用细胞介导的细胞溶解、血清学和分子生物学方法进行的实验表明,EC细胞确实表达一些主要组织相容性复合体(MHC)I类或I类样分子。