Azerbaijan Medical University, Faculty of Medicine, Department of Medical Biochemistry, Baku, Azerbaijan.
Ataturk University, Faculty of Medicine, Department of Medical Biochemistry, Erzurum, Turkey.
Pan Afr Med J. 2022 Feb 3;41:98. doi: 10.11604/pamj.2022.41.98.23415. eCollection 2022.
boxing and kick boxing are combat sports that can cause severe head, neck, face and hand injuries during fighting. Then, traumatic brain injury (TBI) incidence is high in these sports. Ischemia-modified albumin (IMA), brain natriuretic peptide (BNP) and copeptin have diagnostic and prognostic value for cardiac and non-cardiac ischemic events. The purpose of this study is to evaluate exercise-induced variations of serum IMA, BNP and copeptin.
twenty male boxers, twenty-three male kick boxers and twenty-three age-matched male were enrolled in the study. Health assessment data were analysed. Boxers and kick boxers underwent an exercise program including training plus fighting matches. Serum samples were collected in the pre- and post-exercise periods. Serum IMA, BNP and copeptin concentrations were measured in these specimens using ELISA reagents.
comparative analysis of analytes before and after exercise showed that exercise significantly increased serum IMA, BNP and copeptin levels both in boxers and kick boxers.
in conclusion, IMA, BNP and copeptin levels may be candidate biomarkers for exercise-related traumatic brain injuries. The identification of new biomarkers in patients with acute and chronic neurological disorders is of considerable interest to clinicians. Then, further studies should be conducted to evaluate the possible role of IMA, BNP and copeptin in TBI pathophysiology.
拳击和踢拳是格斗运动，在比赛中会导致头部、颈部、面部和手部严重受伤。在这些运动中，创伤性脑损伤（TBI）的发病率很高。缺血修饰白蛋白（IMA）、脑利钠肽（BNP）和 copeptin 对心脏和非心脏缺血事件具有诊断和预后价值。本研究旨在评估运动诱导的血清 IMA、BNP 和 copeptin 的变化。
研究纳入了 20 名男性拳击手、23 名男性踢拳手和 23 名年龄匹配的男性。分析了健康评估数据。拳击手和踢拳手进行了包括训练和比赛在内的运动计划。在运动前后采集血清样本。使用 ELISA 试剂测定这些标本中的血清 IMA、BNP 和 copeptin 浓度。
运动前后分析物的比较分析表明，运动显著增加了拳击手和踢拳手的血清 IMA、BNP 和 copeptin 水平。
总之，IMA、BNP 和 copeptin 水平可能是与运动相关的创伤性脑损伤的候选生物标志物。在急性和慢性神经疾病患者中识别新的生物标志物对临床医生具有重要意义。然后，应该进行进一步的研究来评估 IMA、BNP 和 copeptin 在 TBI 病理生理学中的可能作用。
