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基于临床结局的老年破裂颅内动脉瘤患者显微手术术前量表提案。

Preoperative scale proposal based on clinical outcome for elderly patients with ruptured intracranial aneurysms undergoing microsurgery.

机构信息

Institute of Medical Assistance to the State Public Servant, Leforte Liberty Hospital, Santa Paula Hospital, São Paulo, Brazil.

ABC Medical School, São Paulo, Brazil.

出版信息

Int J Neurosci. 2023 Dec;133(10):1204-1210. doi: 10.1080/00207454.2022.2070488. Epub 2022 Jun 20.

Abstract

INTRODUCTION

Life expectancy in individuals has increased in recent years. There is no consensus in the literature on the best treatment for a ruptured aneurysm in the elderly (> 60 years), but some places only have microsurgery as a therapeutic strategy. This work aims to develop a prognostic scale for ruptured intracranial aneurysms in the elderly.

MATERIAL AND METHODS

Two thousand five hundred thirty patients with subarachnoid hemorrhage were retrospectively evaluated in the last ten years, and 550 of them were elderly. We developed a prognostic scale from the analysis of medical records, clinical and tomographic features that had statistical significance. Glasgow Coma Outcome (GOS) was the outcome of interest and value < 0,05 was considered statistically significant.

RESULTS

Five hundred fifty patients were evaluated, and the comorbidities that were independent variables for poor prognosis were smoking and arterial hypertension; clinical variables were Hunt-Hess, modified Rankin and Glasgow Coma Scale; tomographic was Fisher scale. Poor outcome was defined as GOS ≤ 3. Poor surgical outcomes were more remarkable in the high-risk factor categories, being 6.41 times higher among individuals who had 3 to 4 risk factors and 8.80 times higher among individuals with 5 to 6 risk factors.

CONCLUSION

In some vascular neurosurgery services worldwide, microsurgery is the only therapeutic option. This scale aimed at the elderly patient individualizes the treatment and can predict the clinical outcome in ruptured intracranial aneurysms.

摘要

简介

近年来,个体的预期寿命有所增加。对于老年人(> 60 岁)破裂的动脉瘤,文献中尚无最佳治疗方法的共识,但有些地方仅将显微手术作为治疗策略。这项工作旨在为老年人颅内破裂动脉瘤制定一个预后评分。

材料和方法

在过去十年中,对 2530 名蛛网膜下腔出血患者进行了回顾性评估,其中 550 名是老年人。我们从具有统计学意义的病历、临床和影像学特征分析中开发了一个预后评分。格拉斯哥预后评分(GOS)是感兴趣的结果,< 0.05 被认为具有统计学意义。

结果

评估了 550 例患者,独立预测不良预后的合并症是吸烟和动脉高血压;临床变量是 Hunt-Hess、改良 Rankin 和格拉斯哥昏迷量表;影像学变量是 Fisher 量表。不良结局定义为 GOS ≤ 3。在高风险因素类别中,手术结局更差,有 3-4 个危险因素的个体风险增加 6.41 倍,有 5-6 个危险因素的个体风险增加 8.80 倍。

结论

在世界上一些血管神经外科服务中,显微手术是唯一的治疗选择。该评分针对老年患者个体化治疗,并可预测颅内破裂动脉瘤的临床结局。

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