Kuo Che Yu, Chen Kao Chin, Lee I Hui, Tseng Huai-Hsuan, Chiu Nan Tsing, Chen Po See, Yang Yen Kuang, Chang Wei Hung
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Clin Psychopharmacol Neurosci. 2022 May 31;20(2):271-278. doi: 10.9758/cpn.2022.20.2.271.
The impact of serotonergic system on obsessive-compulsive disorder (OCD) is well studied. However, the correlation between OC presentations and autonomic nervous system (ANS) is still unclear. Furthermore, whether the correlation might be modulated by serotonin is also uncertain.
We recruited eighty-nine healthy subjects. Serotonin transporter (SERT) availability by [I]ADAM and heart rate variability (HRV) tests were measured. Symptoms checklist-90 was measured for the OC presentations. The interaction between HRV and SERT availability were calculated and the correlation between HRV and OC symptoms were analyzed after stratified SERT level into two groups, split at medium.
The interactions were significant in the factors of low frequency (LF), high frequency (HF), and root mean square of successive differences (RMSSD). Furthermore, the significantly negative correlations between OC symptoms and the above HRV indexes existed only in subjects with higher SERT availability.
OC symptoms might be correlated with ANS regulations in subjects with higher SERT availability.
血清素能系统对强迫症（OCD）的影响已得到充分研究。然而，强迫症状与自主神经系统（ANS）之间的相关性仍不明确。此外，这种相关性是否可能受血清素调节也不确定。
我们招募了89名健康受试者。通过[I]ADAM测量血清素转运体（SERT）可用性，并进行心率变异性（HRV）测试。采用症状自评量表-90评估强迫症状。计算HRV与SERT可用性之间的相互作用，并在将SERT水平按中位数分为两组后，分析HRV与强迫症状之间的相关性。
在低频（LF）、高频（HF）和逐差均方根（RMSSD）因素中，相互作用显著。此外，仅在SERT可用性较高的受试者中，强迫症状与上述HRV指标之间存在显著负相关。
在SERT可用性较高的受试者中，强迫症状可能与自主神经系统调节有关。
