1st Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Cancer Invest. 2022 Sep;40(8):733-741. doi: 10.1080/07357907.2022.2070918. Epub 2022 May 9.
We searched international databases to identify evidence that refer to the impact of perineural invasion on survival outcomes of patients with squamous cell vulvar cancer. We identified six retrospective cohort studies that investigated 887 patients. Of those, 234 (26.4%) had perineural invasion in the pathology analysis. Women with perineural invasion were more likely to have inguinal lymph node metastases (HR 3.45, 95% CI 1.12, 10.67). The impact of perineural invasion on progression-free survival rates was significant (HR 1.61, 95% CI 1.21, 2.15) as well as its impact on overall survival rates (HR 2.73, 95% CI 1.94, 3.84).
我们检索了国际数据库，以确定与神经周围侵犯对鳞状细胞外阴癌患者生存结果的影响相关的证据。我们确定了六项回顾性队列研究，共纳入了 887 名患者。其中，234 名（26.4%）在病理分析中存在神经周围侵犯。神经周围侵犯的女性更有可能发生腹股沟淋巴结转移（HR 3.45，95%CI 1.12，10.67）。神经周围侵犯对无进展生存率的影响具有显著性（HR 1.61，95%CI 1.21，2.15），对总生存率的影响也具有显著性（HR 2.73，95%CI 1.94，3.84）。
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