Department of Psychiatry.
Providence Veterans Affairs Medical Center.
J Psychopathol Clin Sci. 2022 Jul;131(5):457-466. doi: 10.1037/abn0000757. Epub 2022 Apr 25.
Familial risk for depression is associated with youth exposure to self-generated dependent stressful life events and independent events that are out of youth's control. Familial risk includes both genetic and environmental influences, raising the question of whether genetic influences, specifically, are associated with youth exposure to both dependent and independent stressful life events. To address this question, this study examined the relation between a genome-wide association study (GWAS)-derived depression-based polygenic risk score (DEP-PRS) and youth experiences of dependent and independent stress. Participants were 180 youth (ages 8 to 14, 52.2% female) of European ancestry and their biological mothers recruited based on the presence versus absence of a history of major depressive disorder (MDD) in the mothers. Youth and mothers were interviewed every 6 months for 2 years regarding the occurrence of stressful life events, which were coded as independent or dependent (self-generated). Results indicated that youth's DEP-PRS and maternal history of MDD were uniquely associated with increased exposure to both dependent and independent events. Similar results were observed when examining major versus minor events separately, with the additional finding of a DEP-PRS × mother MDD interaction for major dependent events such that levels of moderate to severe dependent life stressors were highest among youth with high DEP-PRSs who also had mothers with MDD. These results not only support the presence of depression-relevant gene-environment correlations (rGEs), but also highlight the possibility that rather than only capturing depression-specific genetic liability, GWAS-derived polygenic risk scores may also capture genetic variance contributing to stress exposure. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
抑郁的家族风险与年轻人经历的自我产生的依赖压力生活事件和超出年轻人控制的独立事件有关。家族风险包括遗传和环境影响，这引发了一个问题，即遗传影响是否与年轻人经历依赖和独立压力生活事件有关。为了解决这个问题，本研究考察了基于全基因组关联研究（GWAS）的抑郁多基因风险评分（DEP-PRS）与年轻人经历的依赖和独立压力之间的关系。参与者是 180 名欧洲血统的年轻人（年龄 8 至 14 岁，52.2%为女性）及其生物母亲，根据母亲是否存在或不存在重度抑郁症（MDD）病史招募。在 2 年的时间里，每 6 个月对年轻人和母亲进行一次访谈，了解压力生活事件的发生情况，这些事件被编码为独立事件或依赖事件（自我产生）。结果表明，年轻人的 DEP-PRS 和母亲的 MDD 病史与依赖和独立事件的暴露增加有独特的关联。当分别检查主要事件和次要事件时，也观察到了类似的结果，此外，对于主要依赖事件，还观察到了 DEP-PRS×母亲 MDD 的相互作用，即具有 MDD 的高 DEP-PRS 的年轻人经历的中度至重度依赖生活压力源水平最高。这些结果不仅支持存在与抑郁相关的基因-环境相关（rGE），而且还强调了一个可能性，即 GWAS 衍生的多基因风险评分可能不仅捕捉到了特定于抑郁的遗传易感性，还可能捕捉到了导致压力暴露的遗传变异。（PsycInfo 数据库记录（c）2022 APA，保留所有权利）。
