Paul Bichitra, Lewinska Monika, Andersen Jesper B
Biotech Research & Innovation Center (BRIC), Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
JHEP Rep. 2022 Mar 26;4(6):100479. doi: 10.1016/j.jhepr.2022.100479. eCollection 2022 Jun.
Lipids are a complex and diverse group of molecules with crucial roles in many physiological processes, as well as in the onset, progression, and maintenance of cancers. Fatty acids and cholesterol are the building blocks of lipids, orchestrating these crucial metabolic processes. In the liver, lipid alterations are prevalent as a cause and consequence of chronic hepatitis B and C virus infections, alcoholic hepatitis, and non-alcoholic fatty liver disease and steatohepatitis. Recent developments in lipidomics have also revealed that dynamic changes in triacylglycerols, phospholipids, sphingolipids, ceramides, fatty acids, and cholesterol are involved in the development and progression of primary liver cancer. Accordingly, the transcriptional landscape of lipid metabolism suggests a carcinogenic role of increasing fatty acids and sterol synthesis. However, limited mechanistic insights into the complex nature of the hepatic lipidome have so far hindered the development of effective therapies.
脂质是一类复杂多样的分子，在许多生理过程以及癌症的发生、发展和维持中都起着关键作用。脂肪酸和胆固醇是脂质的组成成分，它们共同协调这些关键的代谢过程。在肝脏中，脂质改变作为慢性乙型和丙型肝炎病毒感染、酒精性肝炎、非酒精性脂肪性肝病和脂肪性肝炎的病因和结果很常见。脂质组学的最新进展还表明，三酰甘油、磷脂、鞘脂、神经酰胺、脂肪酸和胆固醇的动态变化参与了原发性肝癌的发生和发展。因此，脂质代谢的转录图谱表明脂肪酸和甾醇合成增加具有致癌作用。然而，迄今为止，对肝脏脂质组复杂性质的机制了解有限，阻碍了有效疗法的开发。
