质膜钙ATP酶，一种tau蛋白诱导的胞质钙失调的分子靶点。
The Plasma Membrane Ca-ATPase, a Molecular Target for Tau-induced Cytosolic Calcium Dysregulation.
作者信息
Berrocal María, Mata Ana M
机构信息
Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, 06006 Badajoz, Spain; Instituto de Biomarcadores de Patologías Moleculares, Universidad de Extremadura, 06006 Badajoz, Spain.
Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, 06006 Badajoz, Spain; Instituto de Biomarcadores de Patologías Moleculares, Universidad de Extremadura, 06006 Badajoz, Spain.
出版信息
Neuroscience. 2023 May 10;518:112-118. doi: 10.1016/j.neuroscience.2022.04.016. Epub 2022 Apr 22.
Disruption of calcium (Ca) homeostasis is emerging as a prevalent feature of aging and aging-associated neurodegenerative diseases, including Alzheimer's disease (AD), the most common type of tauopathy. This disease is characterized by the combined presence of extracellular neuritic plaques composed by amyloid β-peptides (Aβ) and neurofibrillary tangles of tau. The association of calcium dyshomeostasis with Aβ has been extensively studied, however its link with tau has been less investigated. Thus, this review will concentrate on the functional link between tau and the plasma membrane Ca pump (PMCA) and other membrane proteins involved in the regulation of intracellular calcium and/or its association with neurodegeneration.
钙（Ca）稳态的破坏正成为衰老及与衰老相关的神经退行性疾病（包括最常见的tau蛋白病——阿尔茨海默病（AD））的一个普遍特征。该疾病的特征是由淀粉样β肽（Aβ）组成的细胞外神经炎性斑块和tau蛋白神经原纤维缠结同时存在。钙稳态失调与Aβ之间的关联已得到广泛研究，然而其与tau蛋白的联系研究较少。因此，本综述将专注于tau蛋白与质膜钙泵（PMCA）以及其他参与细胞内钙调节的膜蛋白之间的功能联系，及其与神经退行性变的关联。
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