Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
Department of Pediatrics, Konkuk University Medical Center, Seoul, Korea.
J Korean Med Sci. 2022 Apr 25;37(16):e127. doi: 10.3346/jkms.2022.37.e127.
This meta-analysis was performed to examine the association between maternal hypertension during pregnancy (HDP) and neonatal bronchopulmonary dysplasia (BPD).
We systematically searched PubMed, EMBASE, the Cochrane Library, and the KoreaMed database for relevant studies. We used the Newcastle-Ottawa Scale for quality assessment of all included studies. The meta-analysis was performed using Comprehensive Meta-Analysis software (version 3.3).
We included 35 studies that fulfilled the inclusion criteria; the total number of infants evaluated came to 97,399 through review process. Maternal HDP was not significantly associated with any definition of BPD, i.e., oxygen dependency at 36 weeks of gestation (odds ratio [OR], 1.162; 95% confidence interval [CI], 0.991-1.362; = 0.064) in pooled analysis of 29 studies or oxygen dependency at 28 days of age (OR, 1.084; 95% CI, 0.660-1.780; = 0.751) in pooled analysis of 8 studies. Maternal HDP was significantly associated only with severe BPD (OR, 2.341; 95% CI, 1.726-3.174; < 0.001). BPD was not associated with HDP in the overall analysis (OR, 1.131; 95% CI, 0.977-1.309; = 0.100) or subgroup analysis according to the definition of HDP.
Maternal HDP was not associated with neonatal BPD defined by the duration of oxygen dependency (at either 36 weeks of gestation or 28 days of life) but was associated with severe BPD.
本荟萃分析旨在研究孕妇高血压（HDP）与新生儿支气管肺发育不良（BPD）之间的关联。
我们系统地检索了 PubMed、EMBASE、Cochrane 图书馆和 KoreaMed 数据库中的相关研究。我们使用纽卡斯尔-渥太华量表对所有纳入研究进行质量评估。使用 Comprehensive Meta-Analysis 软件（版本 3.3）进行荟萃分析。
我们纳入了 35 项符合纳入标准的研究；通过审查过程，评估的婴儿总数达到 97399 例。荟萃分析显示，HDP 与任何 BPD 定义均无显著相关性，即 29 项研究的汇总分析中，妊娠 36 周时需要吸氧（比值比 [OR]，1.162；95%置信区间 [CI]，0.991-1.362； = 0.064）或 8 项研究的汇总分析中，出生后 28 天需要吸氧（OR，1.084；95%CI，0.660-1.780； = 0.751）。HDP 仅与严重 BPD 显著相关（OR，2.341；95%CI，1.726-3.174； < 0.001）。在总体分析中，BPD 与 HDP 无相关性（OR，1.131；95%CI，0.977-1.309； = 0.100）或根据 HDP 定义的亚组分析中均无相关性。
HDP 与以吸氧时间（妊娠 36 周或 28 天）定义的新生儿 BPD 无相关性，但与严重 BPD 相关。
