Queisser W, Flechtner H
Onkologie. 1986 Dec;9(6):319-31. doi: 10.1159/000216044.
The results of current chemotherapeutic treatment for advanced gastric carcinoma are reviewed. Recent results of phase-II trials suggest that besides 5-fluorouracil, the nitrosoureas, adriamycin and mitomycin C, cis-platinum is also an effective drug in advanced gastric carcinoma. The favorable results obtained with the FAM-regimen in the late seventies, which were believed to be a significant step towards an improved treatment of gastric carcinoma, could not be confirmed, and several tested FAM-modifications were not able to improve treatment results. However, some recent investigations of cis-platinum within combination chemotherapy, i.e. with 5-fluorouracil and adriamycin (FAP), showed response rates beyond 30% and possibly a prolongation of median survival. These favorable data, which suggest an encouraging progress within the treatment of advanced gastric carcinoma, have to be confirmed in further controlled clinical trials.
本文综述了晚期胃癌当前化疗治疗的结果。II期试验的最新结果表明，除了5-氟尿嘧啶、亚硝基脲、阿霉素和丝裂霉素C外，顺铂也是晚期胃癌的一种有效药物。七十年代后期使用FAM方案取得的良好结果，曾被认为是胃癌治疗改进的重要一步，但未能得到证实，并且几种经过测试的FAM改良方案也未能改善治疗效果。然而，最近一些关于顺铂在联合化疗中的研究，即与5-氟尿嘧啶和阿霉素联合（FAP），显示缓解率超过30%，并且可能延长中位生存期。这些有利数据表明晚期胃癌治疗取得了令人鼓舞的进展，但必须在进一步的对照临床试验中得到证实。
