Cardiomyocyte Renewal Laboratory, Texas Heart Institute, 6770 Bertner Avenue, Houston, TX 77030, USA.
Cardiomyocyte Renewal Laboratory, Texas Heart Institute, 6770 Bertner Avenue, Houston, TX 77030, USA; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Dev Cell. 2022 Apr 25;57(8):945-946. doi: 10.1016/j.devcel.2022.04.002.
Mammalian cardiomyocytes (CMs) undergo polyploidization after birth, accompanied by the loss of CM proliferation and regenerative capacity, although why this occurs is still poorly understood. In this issue of Developmental Cell, Gan et al. show that premature CM polyploidization, through defective RNA splicing, is detrimental to ventricular wall growth.
哺乳动物心肌细胞（CMs）在出生后会经历多倍体化，伴随着 CM 增殖和再生能力的丧失，尽管其发生的原因仍知之甚少。在本期《发育细胞》中，Gan 等人表明，通过 RNA 剪接缺陷导致的过早 CM 多倍体化，对心室壁生长是有害的。
