[Pharmacokinetics of cefmenoxime in the aged subject (60 to 90 years of age) after an intravenous injection of 1 g].

A pharmacokinetic study of Cefmenoxime (CMX) has been carried out in 17 patients, 60 to 90 years old, following IV injection of 1 gram. Plasma concentrations of CMX were determined in 15 blood samples drawn between 0.25-12th hour by a specific high pressure liquid chromatography. The apparent terminal half lives calculated by regression analysis ranged from 0.94 to 3.8 h. We observed an increase of apparent elimination half life and a decrease of total clearance with aging as compared to that of healthy young subjects. Apparent volume of distribution seemed not to differ from those observed in young adults. There is a correlation between renal function and elimination kinetics of Cefmenoxime. In spite of kinetics modifications, it seems that it is not necessary to modify the dosage regimen in elderly.