Influence of Microcirculatory Dysfunction on Myocardial Injury after Cardiopulmonary Resuscitation.

OBJECTIVE

This study aimed to examine the effects of microcirculatory dysfunction and 654-1 intervention after cardiopulmonary resuscitation on myocardial injury.

METHODS

Landrace pigs were divided into a sham operation group (S group, = 6), ventricular fibrillation control group (VF-C group, = 8) and 654-1 intervention group (VF-I group, = 8). Hemodynamics was recorded at baseline, at recovery of spontaneous circulation (ROSC), and 1 h, 2 h, 4 h and 6 h thereafter. Sidestream dark field (SDF) technology was used to evaluate and monitor the microcirculation flow index, total vessel density, perfusion vessel ratio, De-Backer score, and perfusion vessel density in animal viscera at various time points.

RESULTS

After administration of 654-1 at 1.5 h post-ROSC, the hemodynamics in the VF-I group, as compared with the VF-C group, was significantly improved. The visceral microcirculation detected by SDF was also significantly improved in the VF-I group. As observed through electron microscopy, significantly less myocardial tissue injury was present in the VF-I group than the VF-C group.

CONCLUSION

Administration of 654-1 inhibited excessive inflammatory by improving the state of visceral microcirculation.