College of Chemical Engineering, State Key Laboratory Breeding Base of Green-Chemical Synthesis Technology, Zhejiang University of Technology, Chaowang Road 18#, Hangzhou 310014, China.
Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, School of Science, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China.
Chem Commun (Camb). 2022 May 12;58(39):5893-5896. doi: 10.1039/d2cc01650h.
A NiH-catalyzed intermolecular dearomative hydroalkylation of indoles has been developed, which assembles an array of structurally diverse C2-alkylated indolines with moderate to excellent yields. This protocol exhibits good functional group tolerance, allowing for late-stage functionalization of complex drug molecules.
发展了一种 NiH 催化的吲哚分子间去芳构化氢烷基化反应，该反应以中等至优秀的收率构建了一系列结构多样的 C2-烷基化吲哚啉。该方法对官能团具有良好的耐受性，允许对复杂药物分子进行后期的官能团化。
