Suzuki Iku, Nakao Ryohei, Unai Yuki, Miyazaki Yoshimichi
Department of Neurology, Hyogo Prefectural Awaji Medical Center.
Rinsho Shinkeigaku. 2022 May 31;62(5):363-368. doi: 10.5692/clinicalneurol.cn-001684. Epub 2022 Apr 26.
We have reported a case of a 44-year-old woman with anti-signal recognition particle (SRP) antibody-positive immune-mediated necrotizing myopathy triggered by human parvovirus B19 (PVB19) infection. She was admitted to the hospital because of lower leg edema and muscle weakness after erythema infectiosum. Magnetic resonance imaging of the lower extremities revealed high signals in the proximal muscles and subcutaneous edema on STIR. Muscle biopsy showed myofiber regenerative changes and variation in fiber size. A myositis-specific autoantibody profile indicated a positive result for anti-SRP antibodies. We diagnosed the patient with immune-mediated necrotizing myopathy (IMNM). Muscle strength and subcutaneous edema improved gradually in 3 months following immunotherapy. This is the first case report of an IMNM associated with PVB19 infection.
我们报告了一例44岁女性，其抗信号识别颗粒（SRP）抗体阳性的免疫介导坏死性肌病由人细小病毒B19（PVB19）感染引发。她因传染性红斑后出现小腿水肿和肌肉无力入院。下肢磁共振成像显示近端肌肉在短TI反转恢复序列（STIR）上呈高信号及皮下水肿。肌肉活检显示肌纤维再生改变和纤维大小变异。肌炎特异性自身抗体谱显示抗SRP抗体呈阳性结果。我们诊断该患者为免疫介导坏死性肌病（IMNM）。免疫治疗后3个月，肌肉力量和皮下水肿逐渐改善。这是首例与PVB19感染相关的IMNM病例报告。
