Department of Dermatology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Canakkale, Turkey.
Medical Biochemistry, Faculty of Medicine, Çanakkale Onsekiz Mart University, Canakkale, Turkey.
Clin Exp Dermatol. 2022 Sep;47(9):1673-1678. doi: 10.1111/ced.15239. Epub 2022 Jun 22.
Psoriasis is a chronic inflammatory skin disorder characterized by inflammation, hyperproliferation and neoangiogenesis. The disease pathogenesis has not been fully elucidated. The proteins, a disintegrin and metalloproteinase (ADAM)10 and ADAM17, are important proteases serving as regulators of inflammation.
To determine the role of ADAM10 and ADAM17 in the pathogenesis of psoriasis through the comparison of their serum levels in patients with psoriasis and healthy controls (HCs).
In total, 179 participants (90 patients with psoriasis and 89 HCs) were enrolled in the study. Levels of ADAM10 and ADAM17 in serum were measured by ELISA for each participant from the patient and HC groups. The statistical data analysis was performed using SPSS (V19.0) and P < 0.05 was considered statistically significant.
The mean values for serum ADAM10 and ADAM17 were, respectively, 3.1 ± 2.2 and 76.5 ± 31.1 in the psoriasis group and 8.6 ± 3.7 and 29.5 ± 22.4 in the HC group. A statistically significant difference between the patient and HC groups was detected for both ADAM10 and ADAM17 levels (P = 0.001).
Considering the high levels of ADAM17 in the psoriasis group, ADAM17 protease might have a crucial role in the pathogenesis of psoriasis, while the low levels of ADAM10 might be attributable to its regulatory effect on keratinocyte differentiation and proliferation.
银屑病是一种慢性炎症性皮肤疾病，其特征为炎症、过度增殖和新生血管形成。其发病机制尚未完全阐明。解整合素金属蛋白酶（ADAM）10 和 ADAM17 是重要的蛋白酶，作为炎症的调节剂。
通过比较银屑病患者和健康对照者（HC）血清中 ADAM10 和 ADAM17 的水平，确定 ADAM10 和 ADAM17 在银屑病发病机制中的作用。
共纳入 179 名参与者（90 名银屑病患者和 89 名 HC）。使用 ELISA 法测量每位患者和 HC 组中血清 ADAM10 和 ADAM17 的水平。使用 SPSS（V19.0）进行统计数据分析，P＜0.05 为具有统计学意义。
银屑病组血清 ADAM10 和 ADAM17 的平均值分别为 3.1±2.2 和 76.5±31.1，HC 组分别为 8.6±3.7 和 29.5±22.4。ADAM10 和 ADAM17 水平在患者组和 HC 组之间存在统计学差异（P=0.001）。
考虑到银屑病组中 ADAM17 的高水平，ADAM17 蛋白酶可能在银屑病发病机制中具有关键作用，而 ADAM10 的低水平可能归因于其对角质形成细胞分化和增殖的调节作用。
