伴有慢性粒单核细胞白血病的母细胞性树突状细胞肿瘤。
Blastic Indeterminate Dendritic Cell Tumor Associated With Chronic Myelomonocytic Leukemia.
机构信息
Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
出版信息
Am J Dermatopathol. 2022 Sep 1;44(9):691-695. doi: 10.1097/DAD.0000000000002202. Epub 2022 Apr 11.
Indeterminate dendritic cell tumor (IDCT) is an exceedingly rare neoplasm that can be associated with hematopoietic malignancies. We report a case of multifocal cutaneous blastic indeterminate dendritic cell tumor (BIDCT) in a 75-year-old man with chronic myelomonocytic leukemia showing blastic histiocytoid morphology, positivity for CD1a and S100, and no expression of langerin. We present a literature review on the 11 reported cases of IDCTs/BIDCTs associated with chronic myelomonocytic leukemia (CMML), including this case. The clinicopathological characteristics have been summarized. The IDCT and CMML cells are clonally related in 4 tested cases. Patients with IDCT/BIDCT associated with CMML seem to have worse clinical outcomes compared with patients with IDCT not associated with CMML.
不典型树突状细胞瘤（IDCT）是一种非常罕见的肿瘤，可与血液恶性肿瘤相关。我们报告了一例 75 岁男性患有慢性粒单核细胞白血病的多灶性皮肤原始细胞性不典型树突状细胞瘤（BIDCT），其表现为原始细胞性组织细胞样形态，CD1a 和 S100 阳性，朗格汉斯细胞无表达。我们对 11 例伴有慢性粒单核细胞白血病（CMML）的 IDCT/BIDCT 进行了文献复习，包括本病例。总结了其临床病理特征。在 4 例检测的病例中，IDCT 和 CMML 细胞具有克隆相关性。与不伴有 CMML 的 IDCT 患者相比，伴有 IDCT/BIDCT 的 CMML 患者的临床结局似乎更差。
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