• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

免疫检查点B7-H3（CD276）调节脂肪细胞祖细胞代谢和肥胖症发展。

The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development.

作者信息

Picarda Elodie, Galbo Phillip M, Zong Haihong, Rajan Meenu Rohini, Wallenius Ville, Zheng Deyou, Börgeson Emma, Singh Rajat, Pessin Jeffrey, Zang Xingxing

机构信息

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

出版信息

Sci Adv. 2022 Apr 29;8(17):eabm7012. doi: 10.1126/sciadv.abm7012. Epub 2022 Apr 27.

DOI:10.1126/sciadv.abm7012
PMID:35476450
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9045715/
Abstract

The immune checkpoint B7-H3 (CD276) is a member of the B7 family that has been studied in the tumor microenvironment and immunotherapy, but its potential role in metabolism remains largely unknown. Here, we show that B7-H3 is highly expressed in mouse and human adipose tissue at steady state, with the highest levels in adipocyte progenitor cells. B7-H3 is rapidly down-regulated upon the initiation of adipocyte differentiation. Combined RNA sequencing and metabolic studies reveal that B7-H3 stimulates glycolytic and mitochondrial activity of adipocyte progenitors. Loss of B7-H3 in progenitors results in impaired oxidative metabolism program and increased lipid accumulation in derived adipocytes. Consistent with these observations, mice knocked out for B7-H3 develop spontaneous obesity, metabolic dysfunction, and adipose tissue inflammation. Our results reveal an unexpected metabolic role for B7-H3 in adipose tissue and open potential new avenues for the treatment of metabolic diseases by targeting the B7-H3 pathway.

摘要

免疫检查点B7-H3（CD276）是B7家族的成员，已在肿瘤微环境和免疫治疗中得到研究，但其在代谢中的潜在作用仍 largely未知。在这里，我们表明B7-H3在稳态下在小鼠和人类脂肪组织中高度表达，在脂肪细胞祖细胞中水平最高。脂肪细胞分化开始时，B7-H3迅速下调。联合RNA测序和代谢研究表明，B7-H3刺激脂肪细胞祖细胞的糖酵解和线粒体活性。祖细胞中B7-H3的缺失导致氧化代谢程序受损，衍生脂肪细胞中脂质积累增加。与这些观察结果一致，敲除B7-H3的小鼠会出现自发性肥胖、代谢功能障碍和脂肪组织炎症。我们的结果揭示了B7-H3在脂肪组织中意想不到的代谢作用，并为通过靶向B7-H3途径治疗代谢疾病开辟了潜在的新途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f5f/9045715/b43a81c730bf/sciadv.abm7012-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f5f/9045715/1115094353da/sciadv.abm7012-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f5f/9045715/95ca2c174a9d/sciadv.abm7012-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f5f/9045715/93e4aea52b0e/sciadv.abm7012-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f5f/9045715/4506143b64a8/sciadv.abm7012-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f5f/9045715/734d83134f1e/sciadv.abm7012-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f5f/9045715/eeebff9c3ee0/sciadv.abm7012-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f5f/9045715/56096028950f/sciadv.abm7012-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f5f/9045715/354dde8fc53a/sciadv.abm7012-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f5f/9045715/b43a81c730bf/sciadv.abm7012-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f5f/9045715/1115094353da/sciadv.abm7012-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f5f/9045715/95ca2c174a9d/sciadv.abm7012-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f5f/9045715/93e4aea52b0e/sciadv.abm7012-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f5f/9045715/4506143b64a8/sciadv.abm7012-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f5f/9045715/734d83134f1e/sciadv.abm7012-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f5f/9045715/eeebff9c3ee0/sciadv.abm7012-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f5f/9045715/56096028950f/sciadv.abm7012-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f5f/9045715/354dde8fc53a/sciadv.abm7012-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f5f/9045715/b43a81c730bf/sciadv.abm7012-f9.jpg

相似文献

1
The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development.免疫检查点B7-H3（CD276）调节脂肪细胞祖细胞代谢和肥胖症发展。
Sci Adv. 2022 Apr 29;8(17):eabm7012. doi: 10.1126/sciadv.abm7012. Epub 2022 Apr 27.
2
New frontiers in immune checkpoint B7-H3 (CD276) research and drug development.免疫检查点 B7-H3（CD276）研究和药物开发的新前沿。
Mol Cancer. 2023 Mar 2;22(1):43. doi: 10.1186/s12943-023-01751-9.
3
B7-H3/CD276: An Emerging Cancer Immunotherapy.B7-H3/CD276：一种新兴的癌症免疫疗法。
Front Immunol. 2021 Jul 19;12:701006. doi: 10.3389/fimmu.2021.701006. eCollection 2021.
4
Immune checkpoint of B7-H3 in cancer: from immunology to clinical immunotherapy.B7-H3 免疫检查点在癌症中的作用：从免疫学角度到临床免疫治疗。
J Hematol Oncol. 2022 Oct 25;15(1):153. doi: 10.1186/s13045-022-01364-7.
5
CD276 (B7-H3) Maintains Proliferation and Regulates Differentiation in Angiogenic Function in Late Endothelial Progenitor Cells.CD276（B7-H3）在晚期内皮祖细胞的增殖和血管生成功能分化中维持增殖和调节分化。
Stem Cells. 2019 Mar;37(3):382-394. doi: 10.1002/stem.2944. Epub 2018 Nov 28.
6
B7-H3, a checkpoint molecule, as a target for cancer immunotherapy.B7-H3，一种检查点分子，可作为癌症免疫治疗的靶点。
Int J Biol Sci. 2020 Mar 25;16(11):1767-1773. doi: 10.7150/ijbs.41105. eCollection 2020.
7
B7-H3 in Brain Malignancies: Immunology and Immunotherapy.B7-H3 在脑恶性肿瘤中的作用：免疫学和免疫治疗。
Int J Biol Sci. 2023 Jul 24;19(12):3762-3780. doi: 10.7150/ijbs.85813. eCollection 2023.
8
Molecular Pathways: Targeting B7-H3 (CD276) for Human Cancer Immunotherapy.分子途径：靶向B7-H3（CD276）用于人类癌症免疫治疗
Clin Cancer Res. 2016 Jul 15;22(14):3425-3431. doi: 10.1158/1078-0432.CCR-15-2428. Epub 2016 May 20.
9
B7-H3/CD276 Inhibitors: Is There Room for the Treatment of Metastatic Non-Small Cell Lung Cancer?B7-H3/CD276 抑制剂：在转移性非小细胞肺癌的治疗中有一席之地吗？
Int J Mol Sci. 2022 Dec 16;23(24):16077. doi: 10.3390/ijms232416077.
10
The role of B7-H3 in tumors and its potential in clinical application.B7-H3 在肿瘤中的作用及其在临床应用中的潜力。
Int Immunopharmacol. 2021 Dec;101(Pt B):108153. doi: 10.1016/j.intimp.2021.108153. Epub 2021 Oct 19.

引用本文的文献

1
The B7-H3 (CD276) pathway: emerging biology and clinical therapeutics.B7-H3（CD276）通路：新兴生物学与临床治疗学
Trends Pharmacol Sci. 2025 Sep 12. doi: 10.1016/j.tips.2025.08.008.
2
B7-H3/CD276: Novel Immune Checkpoint and Jack of All Trades.B7-H3/CD276：新型免疫检查点及多面手
Immunotargets Ther. 2025 Sep 5;14:967-977. doi: 10.2147/ITT.S534666. eCollection 2025.
3
Research progress of B7-H3 in malignant tumors.B7-H3在恶性肿瘤中的研究进展

本文引用的文献

1
Anti-obesity drug discovery: advances and challenges.抗肥胖药物的发现：进展与挑战。
Nat Rev Drug Discov. 2022 Mar;21(3):201-223. doi: 10.1038/s41573-021-00337-8. Epub 2021 Nov 23.
2
snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis.snRNA-seq 揭示了调节产热的脂肪细胞亚群。
Nature. 2020 Nov;587(7832):98-102. doi: 10.1038/s41586-020-2856-x. Epub 2020 Oct 28.
3
Disturbed mitochondrial dynamics in CD8 TILs reinforce T cell exhaustion.CD8 TIL 中受损的线粒体动力学增强了 T 细胞耗竭。
Front Immunol. 2025 May 30;16:1586759. doi: 10.3389/fimmu.2025.1586759. eCollection 2025.
4
Revealing the mechanisms and therapeutic potential of immune checkpoint proteins across diverse protein families.揭示不同蛋白质家族中免疫检查点蛋白的作用机制和治疗潜力。
Front Immunol. 2025 Apr 28;16:1499663. doi: 10.3389/fimmu.2025.1499663. eCollection 2025.
5
B7-H3 in glioblastoma and beyond: significance and therapeutic strategies.胶质母细胞瘤及其他疾病中的B7-H3：意义与治疗策略
Front Immunol. 2024 Nov 25;15:1495283. doi: 10.3389/fimmu.2024.1495283. eCollection 2024.
6
Sex-Specific Effects of THRβ Signaling on Metabolic Responses to High Fat Diet in Mice.THRβ 信号对高脂饮食诱导的小鼠代谢反应的性别特异性影响。
Endocrinology. 2024 Jul 1;165(8). doi: 10.1210/endocr/bqae075.
7
B7-H3 promotes proliferation and migration of lung cancer cells by modulating PI3K/AKT pathway via ENO1 activity.B7-H3通过ENO1活性调节PI3K/AKT通路促进肺癌细胞的增殖和迁移。
Transl Cancer Res. 2024 Feb 29;13(2):833-846. doi: 10.21037/tcr-23-1537. Epub 2024 Feb 15.
8
A promising target for breast cancer: B7-H3.乳腺癌有希望的治疗靶点：B7-H3。
BMC Cancer. 2024 Feb 7;24(1):182. doi: 10.1186/s12885-024-11933-3.
9
B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention.B7-H3 在肿瘤可塑性和结直肠癌进展之间的十字路口：治疗干预的潜在靶点。
Cancer Metastasis Rev. 2024 Mar;43(1):115-133. doi: 10.1007/s10555-023-10137-8. Epub 2023 Sep 28.
10
B7H3 increases ferroptosis resistance by inhibiting cholesterol metabolism in colorectal cancer.B7H3 通过抑制结直肠癌细胞胆固醇代谢增加铁死亡抵抗能力。
Cancer Sci. 2023 Nov;114(11):4225-4236. doi: 10.1111/cas.15944. Epub 2023 Sep 3.
Nat Immunol. 2020 Dec;21(12):1540-1551. doi: 10.1038/s41590-020-0793-3. Epub 2020 Oct 5.
4
Prevalence of Obesity and Severe Obesity Among Adults: United States, 2017-2018.成年人肥胖和重度肥胖的患病率：美国，2017-2018 年。
NCHS Data Brief. 2020 Feb(360):1-8.
5
The emerging roles of lactate as a redox substrate and signaling molecule in adipose tissues.乳酸在脂肪组织中作为氧化还原底物和信号分子的新兴作用。
J Physiol Biochem. 2020 May;76(2):241-250. doi: 10.1007/s13105-019-00723-2. Epub 2020 Jan 2.
6
White adipose tissue mitochondrial metabolism in health and in obesity.健康与肥胖状态下白色脂肪组织线粒体代谢。
Obes Rev. 2020 Feb;21(2):e12958. doi: 10.1111/obr.12958. Epub 2019 Nov 27.
7
T cell-mediated regulation of the microbiota protects against obesity.T 细胞介导的微生物群调节可预防肥胖。
Science. 2019 Jul 26;365(6451). doi: 10.1126/science.aat9351.
8
Metabolic signatures of cancer cells and stem cells.癌细胞和干细胞的代谢特征。
Nat Metab. 2019 Feb;1(2):177-188. doi: 10.1038/s42255-019-0032-0. Epub 2019 Feb 11.
9
Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes.肥胖症和 2 型糖尿病中的脂肪组织驻留免疫细胞。
Front Immunol. 2019 May 22;10:1173. doi: 10.3389/fimmu.2019.01173. eCollection 2019.
10
The role of interleukin-6 in glucose homeostasis and lipid metabolism.白细胞介素-6 在葡萄糖稳态和脂代谢中的作用。
Semin Immunopathol. 2019 Jul;41(4):491-499. doi: 10.1007/s00281-019-00747-2. Epub 2019 May 17.