Evans R B, Ettensohn D B, Fawaz-Estrup F, Lally E V, Kaplan S R
Semin Arthritis Rheum. 1987 Feb;16(3):196-205. doi: 10.1016/0049-0172(87)90022-9.
Gold lung is a hypersensitivity pneumonitis to gold-containing compounds. It can be distinguished from rheumatoid lung by its subacute or acute onset, diffuse interstitial and/or alveolar filling pattern on chest roentgenogram, presence of lymphocytes on BAL with an inverse helper/suppressor ratio, and response to withdrawal of gold and/or corticosteroid therapy. Other in vitro assays of gold hypersensitivity using peripheral blood lymphocytes are only sporadically positive and, therefore, of limited value in making the diagnosis. Physicians prescribing organic gold compounds should elicit pulmonary complaints throughout the duration of therapy. When patients receiving gold therapy present with signs and symptoms consistent with an acute or subacute hypersensitivity pneumonitis, the gold therapy should be withheld and a diagnostic workup initiated.
金肺是对含金化合物的一种超敏性肺炎。它可通过以下特点与类风湿性肺病相鉴别：起病亚急性或急性，胸部X线片显示弥漫性间质和/或肺泡填充模式，支气管肺泡灌洗显示淋巴细胞存在且辅助/抑制细胞比例倒置，以及对停用金和/或皮质类固醇治疗的反应。其他使用外周血淋巴细胞进行的金超敏体外检测仅偶尔呈阳性，因此在诊断中价值有限。开具有机金化合物处方的医生在整个治疗期间都应询问肺部症状。当接受金治疗的患者出现与急性或亚急性超敏性肺炎相符的体征和症状时，应停用金治疗并开始进行诊断性检查。
