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田纳西州立法对骨科医生阿片类药物处方行为的影响。

Impact of state legislation in Tennessee on opioid prescribing practices of orthopedic surgeons.

机构信息

Department of Pharmacy, Clinical and Administrative Sciences, University of Oklahoma College of Pharmacy, Oklahoma City, Oklahoma. ORCID: https://orcid.org/0000-0003-3842-9059.

Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, Tennessee.

出版信息

J Opioid Manag. 2022 Mar-Apr;18(2):143-149. doi: 10.5055/jom.2022.0704.

Abstract

OBJECTIVE

Post-operative patients are at increased risk of becoming chronic users of opioids, and overprescribing can lead to abuse and diversion. Though data have shown a decrease in opioid prescriptions nationally, limited studies have specifically evaluated the influence of state legislation on this trend. This study aimed to assess the impact of legislation in the state of Tennessee on opioid prescribing amongst orthopedic surgeons.

DESIGN

This retrospective cohort analysis evaluated patients who received opioids post-orthopedic surgery before and after the state legislation was passed.

SETTING

A community teaching hospital.

PATIENTS AND PARTICIPANTS

Two hundred and three post-orthopedic surgery patients were included, with 101 in the preleg-islation and 102 in the post-legislation groups.

INTERVENTIONS

State legislation in Tennessee limiting amounts of prescribed opioids went into effect in July 2018.

MAIN OUTCOME MEASURE(S): The primary outcome was total morphine milligram equivalents (MMEs) prescribed, with secondary outcomes of days' supply, dosage units, and MME per day.

RESULTS

Orthopedic surgery patients in the post-legislation arm were prescribed significantly fewer MME than those in the prelegislation arm (median MME 375 vs. 562.5; p < 0.001). Prescription days' supply, number of dosage units, and MME per day were also significant lower in the post-legislation group.

CONCLUSIONS

After orthopedic surgery, patients in the post-legislation arm were prescribed a median 187.5 MME less than those in the prelegislation arm. Our findings suggest that state opioid legislation is associated with a reduction in the amount of opioids prescribed in certain orthopedic surgery patients, though further studies evaluating adequacy of pain control are warranted.

摘要

目的

术后患者有成为慢性阿片类药物使用者的风险增加,如果过度处方,可能导致滥用和转移。尽管数据显示全国范围内阿片类药物处方数量有所减少,但有限的研究专门评估了州立法对这一趋势的影响。本研究旨在评估田纳西州的立法对骨科医生开具阿片类药物的影响。

设计

这项回顾性队列分析评估了在州立法通过前后接受骨科手术后使用阿片类药物的患者。

设置

一家社区教学医院。

患者和参与者

共有 203 名接受过骨科手术后的患者入组,其中 101 名在立法前,102 名在立法后。

干预措施

田纳西州限制规定剂量阿片类药物的州立法于 2018 年 7 月生效。

主要观察指标

主要结局是开处方的总吗啡毫克当量(MME),次要结局是天数、剂量单位和每天 MME。

结果

立法后组的骨科手术患者开具的 MME 明显少于立法前组(中位数 MME 375 对 562.5;p < 0.001)。处方天数、剂量单位和每天 MME 也显著减少。

结论

在骨科手术后,立法后组的患者开具的 MME 中位数比立法前组少 187.5。我们的研究结果表明,州阿片类药物立法与某些骨科手术患者开具的阿片类药物数量减少有关,尽管需要进一步研究评估疼痛控制的充分性。

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