Chen Wei, Mao Hui, Chen Linxi, Li Lanfang
Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, Hunan, China.
Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, Hunan, China.
Biochim Biophys Acta Mol Cell Res. 2022 Aug;1869(8):119277. doi: 10.1016/j.bbamcr.2022.119277. Epub 2022 Apr 25.
FAM134B is also known as the reticulophagy regulator 1 (RETREG1) or JK-1. FAM134B consists of two long hydrophobic fragments with a reticulon-homology domain, an N-terminal cytoplasmic domain, and a C-terminal cytoplasmic domain. FAM134B plays an important role in regulating selective ER-phagy, and is related to the occurrence and development of many diseases. In the present review, we describe theFAM134B molecular structure, subcellular localization, tissue distribution, and review its mechanisms of action during selective ER-phagy. Furthermore, we summarize the relationship between FAM134B and diseases, including neoplastic diseases, degenerative diseases, central nervous system disease, and infectious diseases. Considering the pleiotropic action of FAM134B, targeting FAM134B may be a potent therapeutic avenue for these diseases.
FAM134B也被称为网织自噬调节因子1（RETREG1）或JK-1。FAM134B由两个带有网织蛋白同源结构域的长疏水片段、一个N端胞质结构域和一个C端胞质结构域组成。FAM134B在调节选择性内质网自噬中起重要作用，并且与许多疾病的发生和发展有关。在本综述中，我们描述了FAM134B的分子结构、亚细胞定位、组织分布，并综述了其在选择性内质网自噬过程中的作用机制。此外，我们总结了FAM134B与疾病之间的关系，包括肿瘤性疾病、退行性疾病、中枢神经系统疾病和感染性疾病。鉴于FAM134B的多效性作用，靶向FAM134B可能是治疗这些疾病的有效途径。
