The Prestage Department of Poultry Science, 334C Scott Hall, North Carolina State University, Raleigh, NC, 27693, USA; Department of Microbiology, North Carolina State University, Raleigh, NC, 27693, USA.
Arch Biochem Biophys. 2022 Sep 15;726:109256. doi: 10.1016/j.abb.2022.109256. Epub 2022 Apr 25.
This commentary discusses how the idea of employing redox cycling compounds to generate partially reduced oxygen species (O, HO, HO) to cause oxidative stress in the model organism, Escherichia coli, was born. The concept was materialized during our studies on the induction and regulation of the Mn-superoxide dismutase in this unicellular organism. I described how the findings revolutionized the field of oxygen free radicals and oxidative stress and demonstrated its continued relevance and impact to the field today and most probably in the future.
这篇评论讨论了利用氧化还原循环化合物产生部分还原氧物种（O、HO、HO）在模式生物大肠杆菌中引起氧化应激的想法是如何产生的。这个概念是在我们对这种单细胞生物的 Mn-超氧化物歧化酶的诱导和调节的研究中实现的。我描述了这些发现如何彻底改变了氧自由基和氧化应激领域，并展示了它在当今和未来的领域中仍然具有相关性和影响力。
