Frykberg E R, Santiago F, Betsill W L, O'Brien P H
Surg Gynecol Obstet. 1987 Mar;164(3):285-301.
Lobular carcinoma in situ of the breast is a well defined pathologic entity which is found in about 2.5 per cent of all specimens of the breast taken for biopsy and most commonly occurs in premenopausal females. Its diagnosis is virtually always incidental due to the absence of any clinical indication of its presence. This lesion carries a significant risk for development of subsequent invasive carcinoma which applies equally to both breasts and which appears to increase with time. The appropriate treatment of this disease remains a controversial issue. Various aspects of its epidemiology, pathology and natural history which have an important bearing on the therapeutic decision as well as the many treatment options available are analyzed herein. There is certainly a perception that lobular carcinoma in situ represent the early form of a malignant process which can be cured or prevented if appropriately treated at this stage. At the very least, an understanding of this lesion holds the potential for broadening our understanding of the physiologic basis of carcinoma of the breast as a whole.
乳腺小叶原位癌是一种定义明确的病理实体，在所有接受活检的乳腺标本中约占2.5%，最常见于绝经前女性。由于没有任何临床迹象表明其存在，其诊断几乎总是偶然发现的。这种病变有发展为后续浸润性癌的重大风险，双侧乳房均会发生，且风险似乎随时间增加。这种疾病的恰当治疗仍然是一个有争议的问题。本文分析了其流行病学、病理学和自然史的各个方面，这些方面对治疗决策有重要影响，同时也分析了现有的多种治疗选择。人们肯定有一种看法，即小叶原位癌代表恶性过程的早期形式，如果在这个阶段得到适当治疗，是可以治愈或预防的。至少，对这种病变的了解有可能拓宽我们对整个乳腺癌生理基础的认识。
