Division of Pharmacogenomics & Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.
Laboratory for Pharmacogenomics, Ramathibodi Hospital, Somdech Phra Debaratana Medical Center SDMC, Bangkok, 10400, Thailand.
Pharmacogenomics. 2022 Jun;23(8):493-503. doi: 10.2217/pgs-2022-0016. Epub 2022 Apr 28.
Autism spectrum disorder (ASD) is a global challenge that may disrupts family and social life significantly. There is robust evidence for the association of a pharmacokinetic gene variant (e.g., ) with risperidone-induced hyperprolactinemia in ASD. Association of a pharmacodynamic gene variant (e.g., ) with risperidone-induced hyperprolactinemia in ASD is also evident from multiple studies. In addition to genetic factors, dose, duration and drug-drug interactions of risperidone might also increase the serum prolactin level. There are several difficulties, such as reimbursement, knowledge and education of healthcare providers, in implementing risperidone pharmacogenomics into clinical practice. However, preparation of national and international pharmacogenomics-based dosing guidelines of risperidone may advance precision medicine of ASD.
自闭症谱系障碍 (ASD) 是一项全球性挑战，可能会严重扰乱家庭和社会生活。有大量证据表明，药物代谢动力学基因变异（例如 ）与 ASD 中利培酮引起的高催乳素血症有关。从多项研究中也可以看出，药物动力学基因变异（例如 ）与 ASD 中利培酮引起的高催乳素血症有关。除遗传因素外，利培酮的剂量、持续时间和药物相互作用也可能会增加血清催乳素水平。将利培酮药物基因组学应用于临床实践存在一些困难，例如报销、医疗保健提供者的知识和教育。然而，制定基于利培酮药物基因组学的国家和国际剂量指南可能会推进 ASD 的精准医学。
