School of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung City, 40201, Taiwan.
Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung, 40201, Taiwan.
BMC Womens Health. 2022 Apr 27;22(1):139. doi: 10.1186/s12905-022-01721-1.
Bet1 Golgi vesicular membrane trafficking protein-like (BET1L) rs2280543 single nucleotide polymorphism (SNP) and diet have been independently associated with uterine leiomyoma (UL). However, whether the SNP and diet could jointly influence the risk of UL is yet to be assessed. Therefore, we investigated the independent and interactive effects of vegetarian diet and BET1L rs2280543 on uterine fibroids in Taiwanese women.
We linked participants' electronic data in the Taiwan Biobank (TWB) database to their medical records in the National Health Insurance Research Database (NHIRD). The TWB had genotypic, lifestyle, and biochemical data between 2008 and 2015 and the NHIRD had data on disease diagnoses between 1998 and 2015. In this study, we included 1997 premenopausal women with complete data.
Compared to participants with the BET1L rs2280543 CC genotype (wildtype), those with CT/CC genotype had an odds ratio (OR) of 0.69 and a 95% confidence interval (CI) of 0.51-0.93. Vegetarian diet and UL were not significantly associated: OR = 1.09 and 95% CI = 0.77-1.55. However, the test for interaction between rs2280543 and vegetarian diet was significant (p = 0.046). Compared to individuals with the CC genotype, the risk of UL was lower among vegetarians with the CT/TT genotype: OR (95% CI) = 0.15 (0.05-0.47).
The BET1L rs2280543 CT/TT genotype was associated with a lower risk of UL especially among vegetarians.
Bet1 高尔基小泡膜转运蛋白样（BET1L）rs2280543 单核苷酸多态性（SNP）和饮食已被独立地与子宫平滑肌瘤（UL）相关联。然而，SNP 和饮食是否可以共同影响 UL 的风险尚待评估。因此，我们研究了素食饮食和 BET1L rs2280543 对台湾女性子宫纤维瘤的独立和交互作用。
我们将台湾生物银行（TWB）数据库中的参与者电子数据与他们在国家健康保险研究数据库（NHIRD）中的医疗记录相链接。TWB 有 2008 年至 2015 年之间的基因型、生活方式和生化数据，NHIRD 有 1998 年至 2015 年之间的疾病诊断数据。在这项研究中，我们纳入了 1997 名有完整数据的绝经前妇女。
与 BET1L rs2280543 CC 基因型（野生型）的参与者相比，CT/CC 基因型的参与者的优势比（OR）为 0.69，95%置信区间（CI）为 0.51-0.93。素食饮食与 UL 无显著相关性：OR=1.09，95%CI=0.77-1.55。然而，rs2280543 和素食饮食之间的交互作用检验具有统计学意义（p=0.046）。与 CC 基因型的个体相比，CT/TT 基因型的素食者 UL 的风险较低：OR（95%CI）=0.15（0.05-0.47）。
BET1L rs2280543 CT/TT 基因型与 UL 的风险降低相关，尤其是在素食者中。
